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MRNet specifications


Unique identifier OMICS_01686
Name MRNet
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Programming languages C++
Computer skills Advanced
Stability Stable
Maintained No


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MRNet citations


Estimation of the proteomic cancer co expression sub networks by using association estimators

PLoS One
PMCID: 5690670
PMID: 29145449
DOI: 10.1371/journal.pone.0188016

[…] (algorithm for the reconstruction of accurate cellular networks–aracne [], context-likelihood of relatedness–clr [], network inference with maximum relevance/minimum redundancy feature selection–mrnet []) by using synthetic and real microarray data sets. in addition, the empirical, mm and shrink estimators were used to examine the equal width (ew) and equal frequency (ef) discretization […]


Exploring candidate biological functions by Boolean Function Networks for Saccharomyces cerevisiae

PLoS One
PMCID: 5628832
PMID: 28981547
DOI: 10.1371/journal.pone.0185475

[…] first category is the weighted network analysis (wgcna) []. representative methods in the second category include the relevance networks (rn) [], the maximum relevance/minimum redundancy network (mrnet) [], the context likelihood relatedness (clr) [] and the algorithm for the reconstruction of accurate cellular networks (aracne) []., methods which are able to establish causality are mostly […]


Revealing protein networks and gene drug connectivity in cancer from direct information

Sci Rep
PMCID: 5473890
PMID: 28623316
DOI: 10.1038/s41598-017-04001-3

[…] used to compute the information dependence between two random variables. many genomic analysis methods are derived from or include mi in their definition. mi based methods, such as aracne, clr, and mrnet, are employed in gene and protein co-expression analysis and ppis determination, . however, mutual information is designed to uncover any kind of relationship among variables making it hard […]


Study of Meta analysis strategies for network inference using information theoretic approaches

BioData Min
PMCID: 5420410
PMID: 28484519
DOI: 10.1186/s13040-017-0136-6

[…] correlation,...), bayesian networks or even ensemble approaches (that combine several different approaches). among those, mutual information (mi) based algorithms, such as clr [], aracne [], mrnet [, ] and so on, gather more and more attention owing to their capability to deal with up to several thousands of variables in the presence of a limited number of samples []. generally, mi-based […]


Enlightening discriminative network functional modules behind Principal Component Analysis separation in differential omic science studies

Sci Rep
PMCID: 5347127
PMID: 28287094
DOI: 10.1038/srep43946

[…] a r/bioconductor package which provides a set of functions to infer mi networks from a dataset. we considered all the inference algorithms (clr, aracne, mrnet, mrnetb), using for mi computation pearson correlation (and other default values)., as in the p-value network, the inferred mi network has coloured nodes colour based on the difference […]


Data driven reverse engineering of signaling pathways using ensembles of dynamic models

PLoS Comput Biol
PMCID: 5319798
PMID: 28166222
DOI: 10.1371/journal.pcbi.1005379

[…] information-theoretic methods for network inference are aracne [], and its extensions td-aracne [] and haracne [], context likelihood of relatedness, (clr) [], minimum redundancy networks (mrnet) [], three-way mutual information (mi3) [], and mutual information distance and entropy reduction (mider) [], to name a few. all of them are based on estimating some information-theoretic […]

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