Mass spectrometry based targeted metabolomics data analysis
Targeted metabolomics assay platforms are extremely useful for hypothesis testing. These experiments require extensive planning to define the key metabolites in biochemical pathways of interest. Rate-limiting precursors, end-product pools, critical intermediates, and potential alternate precursors or products need to be incorporated into an assay platform.
(Wood, 2014) Mass spectrometry strategies for clinical metabolomics and lipidomics in psychiatry, neurology, and neuro-oncology. Neuropsychopharmacology.