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MTLD specifications


Unique identifier OMICS_13840
Alternative name Multiple Target Ligand Database
Restrictions to use None
Database management system MySQL
Community driven No
Data access File download, Browse
User data submission Not allowed
Maintained No

Publication for Multiple Target Ligand Database

MTLD citations


Interaction of Complement Defence Collagens C1q and Mannose Binding Lectin with BMP 1/Tolloid like Proteinases

Sci Rep
PMCID: 5717261
PMID: 29209066
DOI: 10.1038/s41598-017-17318-w

[…] es used were mouse monoclonal anti-C1q (Abcam, clone 9A7, ab71089) and rabbit polyclonal anti-BMP-1 directed against active proteinase (it should be noted that this antibody recognizes both BMP-1 and mTLD as the antigen used is in the catalytic domain which is identical in both proteinases). Secondary antibodies used were, respectively, AlexaFluor 488-conjugated goat anti-mouse IgG and AlexaFluor […]


Draft Genome Sequence of Ochrobactrum intermedium Strain SA148, a Plant Growth Promoting Desert Rhizobacterium

Genome Announc
PMCID: 5334584
PMID: 28254977
DOI: 10.1128/genomeA.01707-16

[…] xyvinyltransferase (EC first identified in Ochrobactrum anthropi (), which is targeted by the herbicide glyphosate. We also detected mannitol-1-phosphate 5-dehydrogenase (EC (gene mtlD) as a part of an osmoprotectant synthesis pathway that can be utilized to improve stress tolerance against temperature fluctuation (). Moreover, a number of genes related to growth-promoting acti […]


Structural characterization of twisted gastrulation provides insights into opposing functions on the BMP signalling pathway

Matrix Biol
PMCID: 5080453
PMID: 26829466
DOI: 10.1016/j.matbio.2016.01.019

[…] 50 μg ml− 1 ∆N-chordin was incubated with 3 μg ml− 1 mTld at 37 °C for 0.5 h. Tsg was added in a 0.1:1, 0.25:1, 0.5:1, 1:1 and 4:1 molar ratio of Tsg:∆N-chordin. At 1:1 or higher rations of Tsg:∆N-chordin an increase in tolloid cleavage was observed. Ge […]


Association between clinical antibiotic resistance and susceptibility of Pseudomonas in the cystic fibrosis lung

PMCID: 4906436
PMID: 27193199
DOI: 10.1093/emph/eow016

[…] eads of each sample to a set of 13 PA14 housekeeping genes [, ] that are used for MLST (multi-locus sequence typing) typing of pseudomonads. The genes included were acsA, adhA, aroE, aph, bdhA, guaA, mtlD, mutL, nucP, nuoD, ppsA, trpE and xdhB. Similarly, we mapped all reads to a set of genes that were known to be commonly involved in antibiotic resistance [,], consisting of the genes ampC, ampD, […]


Diversity between mammalian tolloid proteinases: Oligomerisation and non catalytic domains influence activity and specificity

Sci Rep
PMCID: 4763255
PMID: 26902455
DOI: 10.1038/srep21456

[…] gated using single particle EM with negative staining (). There were two oligomeric states of TLL-2 observed on the EM grid, a monomeric form and a dimer, which was consistent with the shape seen for mTLD and TLL-1 previously. Using reference-free methods, 3D reconstructions were calculated using angular reconstitution. The 3D model generated for the monomer was an elongated asymmetric shape with […]


Utility of Whole Genome Sequencing of Escherichia coli O157 for Outbreak Detection and Epidemiological Surveillance

J Clin Microbiol
PMCID: 4609728
PMID: 26354815
DOI: 10.1128/JCM.01066-15

[…] The databases were then queried with the de novo assemblies. For MLST, the database consisted of the alleles of 15 housekeeping genes (arcA, aroE, aspC, clpX, cyaA, dnaG, fadD, grpE, icdA, lysP, mdh, mtlD, mutS, rpoS, uidA), which were downloaded from the EcMLST website (; for stx subtyping, the database consisted of 600-bp sequences (342 bp of the C-terminal […]


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MTLD institution(s)
North China Institute of Science and Technology, Beijing, China; Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, China; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada
MTLD funding source(s)
This work was in part supported by the Nature Science Foundation of China (81311120299, 81271844) and Fundamental Research Funds for the Central Universities of China (3142014100).

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