MulPSSM statistics

Tool stats & trends

Looking to identify usage trends or leading experts?

MulPSSM specifications


Unique identifier OMICS_21058
Name MulPSSM
Alternative name Multiple position-specific scoring matrices
Restrictions to use None
Community driven No
Data access File download, Browse
User data submission Not allowed
Maintained No


This tool is not available anymore.

Publication for Multiple position-specific scoring matrices

MulPSSM citations


Repertoire of Protein Kinases Encoded in the Genome of Takifugu rubripes

Comp Funct Genomics
PMCID: 3359783
PMID: 22666085
DOI: 10.1155/2012/258284

[…] kinase catalytic domain containing gene products using the HMMer method by querying each of the kinase domain containing proteins against the protein family HMMs available in the Pfam database [] and MULPSSM profiles [, ] of families in Pfam database. Transmembrane segments were detected using TMHMM []. […]


AlignHUSH: Alignment of HMMs using structure and hydrophobicity information

BMC Bioinformatics
PMCID: 3228556
PMID: 21729312
DOI: 10.1186/1471-2105-12-275

[…] %) [] than simple sequence profile search methods such as PSI-BLAST and HMMER2.0 (sensitivity around 20% at superfamily level) []. Some of the recent developments using the PSI-BLAST programs such as MulPSSM [] and Cascade BLAST [] have increased sensitivity of PSI-BLAST methods by a few percentage points, but they may not be suited for homology based structural modeling since they depend on PSI-B […]


Functional diversity of human protein kinase splice variants marks significant expansion of human kinome

BMC Genomics
PMCID: 2805699
PMID: 20028505
DOI: 10.1186/1471-2164-10-622

[…] ous protein kinase subfamilies proposed by Hanks and Hunter classification scheme. RPS-BLAST has been used to search each of the putative protein kinases as a query against the database containing 55 Multiple Position Specific Scoring Matrices (MulPSSMs) created for the various subgroups of protein kinases in each of the subfamilies. Criteria used in identifying kinase subfamilies involved use of […]


Classification of Nonenzymatic Homologues of Protein Kinases

Comp Funct Genomics
PMCID: 2754085
PMID: 19809514
DOI: 10.1155/2009/365637

[…] omain of these PKLNKs has been carried out using HMMer search methods by querying each of the PKLNK against the 10340 protein families HMMs available in the Pfam database ( MulPSSM (Multiple PSSM) [] approach was used further to assign domain to the region which has not been assigned using HMMer approach. Trans-membrane regions were detected using TMHMM []. […]


Comparative kinomics of human and chimpanzee reveal unique kinship and functional diversity generated by new domain combinations

BMC Genomics
PMCID: 2651890
PMID: 19105813
DOI: 10.1186/1471-2164-9-625

[…] Protein kinases are identified using a combination of profile-based search methods such as PSI-BLAST [] and RPS-BLAST [] using multiple profiles (MulPSSM) [,]. MulPSSM approach has been previously benchmarked and has been used in our previous kinome analysis for several other genomes [,,,,]. Summary of the main steps involved in the current ana […]


Looking to check out a full list of citations?

MulPSSM institution(s)
Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India; National Centre for Biological Sciences, GKVK Campus, Bangalore, India
MulPSSM funding source(s)
Supported by Council of Scientific and Industrial Research, New Delhi and Wellcome Trust, London, respectively; International Senior Fellowship in biomedical sciences; by the Wellcome Trust, UK, NMITLI project from CSIR, India and computational genomics project funded by the Department of Biotechnology, India.

MulPSSM reviews

star_border star_border star_border star_border star_border
star star star star star

Be the first to review MulPSSM