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multi-RELIEF specifications


Unique identifier OMICS_07172
Name multi-RELIEF
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes

Publication for multi-RELIEF

multi-RELIEF citations


Uncovering missing pieces: duplication and deletion history of arrestins in deuterostomes

BMC Evol Biol
PMCID: 5501109
PMID: 28683816
DOI: 10.1186/s12862-017-1001-4

[…] R0 including sea urchin ARR0.1. The filtered alignments were analyzed with four complementary SDP detection tools, the entropy-based sequence harmony approach (SH) [, ], the machine-learning approach multi-RELIEF [, ], Xdet, which is based on analysis of mutational behavior [] and S3det based on MCA []. The first two approaches were run via the webserver [], while the latter two are implemented in […]


Proteins and Their Interacting Partners: An Introduction to Protein–Ligand Binding Site Prediction Methods

Int J Mol Sci
PMCID: 4691145
PMID: 26694353
DOI: 10.3390/ijms161226202

[…] learning is applied to PSSMs or multiple sequence alignment-based properties using various alternative strategies, examples of which will now be discussed. Many of the sequence-based methods, such as Multi-RELIEF [], deploy machine learning methods to directly interpret multiple sequence alignment profiles. Multi-RELIEF works by estimating the functional specificity of residues from a multiple seq […]


ss TEA: Entropy based identification of receptor specific ligand binding residues from a multiple sequence alignment of class A GPCRs

BMC Bioinformatics
PMCID: 3162937
PMID: 21831265
DOI: 10.1186/1471-2105-12-332

[…] t is expected to have only a minor effect. Because the theoretically compiled optimal ranking includes information about the location of the pocket we also included this information in the ss-TEA and Multi-Relief method and scored the 22 residues included in the theoretically compiled optimal ranking prior to all other residues. The rankings which include this information will be indicated in this […]


Multiple evidence for the role of an Ovate like gene in determining fruit shape in pepper

BMC Plant Biol
PMCID: 3069956
PMID: 21401913
DOI: 10.1186/1471-2229-11-46

[…] nual curation removing columns having many gap characters. This curated alignment was used for protein subfamily identification employing the SCI-PHY algorithm []. After subfamily identification, the multi-RELIEF Feature Weighting Method [] was employed to detect specificity determining amino-acid residues among subfamilies. For the phylogenetic analysis the MAFFT program was also used. The result […]


Bayesian classification of residues associated with protein functional divergence: Arf and Arf like GTPases

Biol Direct
PMCID: 3012027
PMID: 21129209
DOI: 10.1186/1745-6150-5-66

[…] ergence prediction programs can (this dataset in particular), why should molecular biologists use this particular method as opposed to others that have been published such as DIVERGE [], GroupSim [], Multi-RELIEF [], or similar? The answer is obvious for some of these in that the new method does semi-automated partitioning of sequences and can handle a very large number of sequences. But does this […]


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multi-RELIEF institution(s)
Division of Medical Chemistry, LACDR, Leiden University, RA, Leiden, Netherlands

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