MultiFit statistics

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Associated diseases

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MultiFit specifications


Unique identifier OMICS_23990
Name MultiFit
Software type Application/Script
Interface Web user interface
Restrictions to use None
Input data A set of protein structures and an EM density map.
Input format PDB,MRC
Output data An ensemble of models ranked by their quality of fit to the density map.
Computer skills Basic
Stability Stable
Maintained Yes


  • person_outline Andrej Sali <>
  • person_outline Haim Wolfson <>

Publications for MultiFit

MultiFit in publications

PMCID: 5746781
PMID: 29206205
DOI: 10.3390/bios7040058

[…] (3) kc and kobs = k2[h2o2] are the rate constants of the two reaction steps as defined in , and io is a constant proportional to the initial luminol concentration., a nonlinear least-squares multifit of experimental data in to equation (3) gives the following values of best fit parameters: k2 = (2.5 ± 0.3) × 103 m−1 s−1, kc = 9.0 ± 3.2 s−1. the nice fit of data points to equation (3) […]

PMCID: 5586343
PMID: 28904862
DOI: 10.1002/2211-5463.12269

[…] in a 12‐mm path length six‐sector cell. sedimentation equilibrium profile was measured at 6400 g. data were fitted to a single exponential curve using beckman origin‐based software (version 3.1) multifit option (beckman coulter, indianapolis, in, usa) to determine the weighted average of protein masses., jm designed the study and wrote the manuscript. fz and sek also contributed to writing […]

PMCID: 5440692
PMID: 28504263
DOI: 10.1038/ncomms15247

[…] depending on their orientation relative to the maximum compressive axis. stress in crystals is inferred from lattice strains, recovered from the x-ray diffraction () using the software package multifit-polydefix. the diffracting plane azimuth φ is defined as the angle between the maximum compression axis and the diffracting plane normal, with φ=0 for planes normal to the maximum […]

PMCID: 5427971
PMID: 28331186
DOI: 10.1038/s41598-017-00266-w

[…] 18 symmetrical assemblies for which the multimeric conformation is already known, and compared the results with previously proposed methods including a particle swarm optimization (pso) pow er , multifit and symmdock (see methods and supplementary table ). for each of the assembly cases, em maps at 15 å resolution were synthetically generated and used to rank the best candidate solutions. […]

PMCID: 5290284
PMID: 28134243
DOI: 10.1038/ncomms14310

[…] protomer was then extracted, idealized to improve stereochemistry and used to generate a homo-dodecameric ring inside the symmetrized 8.7 å cryo-em map of p22 pc-portal protein (emd-1828) using multifit. this 12-fold symmetric oligomer was then used as search model for molecular replacement as implemented in phaser, which readily located an unambiguous solution (llg >3,000). a complete […]

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MultiFit institution(s)
Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA; Department of Pharmaceutical Chemistry, and California Institute for Quantitative Biosciences (QB3), University of California, San Francisco, CA, USA; Blavatnik School of Computer Science, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel
MultiFit funding source(s)
Supported by The Clore Foundation Ph.D Scholars program; the Israel Science Foundation (1403/09); the Hermann Minkowski-Minerva Center for Geometry at Tel Aviv University; the Sandler Family Supporting Foundation, National Institutes of Health (R01 GM54762, U54 RR022220, PN2 EY016525 and R01 GM083960), Hewlett-Packard, NetApp, IBM and Intel.

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