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Performs homology searches with operons or gene clusters as basic units, instead of single genes. MultiGeneBlast allows users to get a better understanding of the function, evolutionary history, and practical applications of such genomic regions. It is fully equipped with applications to generate search databases from GenBank or from the user’s own sequence data. MultiGeneBlast provides a general search tool that can be exploited in a wide range of comparative genomics studies of homologous multigene units, by expert bioinformaticians and experimental biologists alike.

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MultiGeneBlast classification

MultiGeneBlast specifications

Software type:
Restrictions to use:
Input format:
Operating system:
Unix/Linux, Mac OS, Windows
GNU General Public License version 3.0
Graphical user interface
Input data:
An annotated genome sequence
Output data:
An interactive XHTML page, in which additional information on each gene appears on mouse-over or by clicking on a gene.
Programming languages:
Computer skills:

MultiGeneBlast distribution


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MultiGeneBlast support



  • Eriko Takano <>


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Department of Microbial Physiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, Netherlands; Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, Netherlands; Faculty of Life Sciences, Manchester Institute of Biotechnology, University of Manchester, Manchester, UK; Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK

Funding source(s)

This work was supported by the Dutch Technology Foundation STW, which is the applied science division of NWO, the Technology Programme of the Ministry of Economic Affairs (grant number STW 10463), an NWO-Vidi fellowship, and a Rosalind Franklin Fellowship, University of Groningen.

Link to literature

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