Multiple sequence alignment (MSA) is the basis for a wide range of comparative sequence analyses from molecular phylogenetics to 3D structure prediction. Sophisticated algorithms have been developed for sequence alignment, but in practice, many errors can be expected and…
Desktop app
PSAR-align PSAR-align

PSAR-align

A multiple sequence realignment tool that can refine a given multiple sequence…

A multiple sequence realignment tool that can refine a given multiple sequence alignment based on suboptimal alignments generated by probabilistic sampling. PSAR-Align is able to improve the results…

Desktop app
Accessory Genome… Accessory Genome Constellation Network

AcCNET Accessory Genome Constellation Network

A Perl application that aims to compare accessory genomes of a large number of…

A Perl application that aims to compare accessory genomes of a large number of genomic units, both at qualitative and quantitative levels. The AcCNET workflow comprises three steps: (i) protein…

Web app
MergeAlign MergeAlign

MergeAlign

Constructs a consensus multiple sequence alignment from multiple independent…

Constructs a consensus multiple sequence alignment from multiple independent alignments. Using dynamic programming MergeAlign efficiently combines individual multiple sequence alignments to generate…

Desktop app
OD-seq OD-seq

OD-seq

A practical and simple method to detect outliers in multiple sequence…

A practical and simple method to detect outliers in multiple sequence alignments (MSAs). OD-seq can also detect outliers in sets of unaligned sequences, but with reduced accuracy. For medium sized…

Desktop app
Noisy Noisy

Noisy

A method that, based on assessing the distribution of character states along a…

A method that, based on assessing the distribution of character states along a cyclic ordering of the taxa, allows the identification of phylogenetically uninformative homoplastic sites in a multiple…

Desktop app
Web app
Transitive… Transitive Consistency Score

TCS Transitive Consistency Score

An alignment evaluation score that makes it possible to identify in an MSA the…

An alignment evaluation score that makes it possible to identify in an MSA the most correct positions. It has been shown that these positions are the most likely to be structurally correct and also…

Desktop app
ZORRO ZORRO

ZORRO

A probabilistic masking program that objectively measures the quality of the…

A probabilistic masking program that objectively measures the quality of the alignment at each individual position. ZORRO uses a pair Hidden Markov Model (pair-HMM) to model the sequence evolution…

Desktop app
Aliscore Aliscore

Aliscore

Identifies random similarity within multiple sequence alignments based on Monte…

Identifies random similarity within multiple sequence alignments based on Monte Carlo resampling within a sliding window. Aliscore infers similarity profiles from pairwise sequence comparisons and…

Desktop app
Web app
trimAl trimAl

trimAl

A tool for automated alignment trimming, which is especially suited for…

A tool for automated alignment trimming, which is especially suited for large-scale phylogenetic analyses. trimAl can consider several parameters, alone or in multiple combinations, for selecting the…

Web app
GUIDANCE GUIDANCE

GUIDANCE

An integrative methodology that accounts for: (i) uncertainty in the process of…

An integrative methodology that accounts for: (i) uncertainty in the process of indel formation, (ii) uncertainty in the assumed guide tree and (iii) co-optimal solutions in the pairwise alignments,…

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