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MuStab specifications


Unique identifier OMICS_08590
Name MuStab
Interface Web user interface
Restrictions to use None
Input data An amino acid sequence.
Input format FASTA
Output data The information about the query sequence and amino acid substitution, the prediction result, and the prediction confidence.
Computer skills Basic
Stability No
Maintained No


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Publication for MuStab

MuStab citations


Influence of protein fold stability on immunogenicity and its implications for vaccine design

PMCID: 5490637
PMID: 28290225
DOI: 10.1080/14760584.2017.1306441

[…] data, but in general are rather runtime-intensive. thus, they are restricted to investigate only a comparably small number of mutations. machine learning methods are either sequence based (e.g. mustab, iptree-stab, inps) or structure based (e.g. inps3d, mcsm, popmusic). they provide good prediction accuracy and in general are faster than the aforementioned methods. hence, they are better […]


A rare nonsynonymous variant in the lipid metabolic gene HELZ2 related to primary biliary cirrhosis in Chinese Han

PMCID: 4819269
PMID: 27047549
DOI: 10.1186/s13223-016-0120-6

[…] for threonine (acg) was highly conserved, with the third varied greatly (fig. b). this mutation was predicted to be possibly damaging with a score of 0.469 by polyphen-2. the web-based software, mustab (predicting mutant protein stability change) was applied to predict if the snp could influence the stability of helz2. under the condition of ph 7.0 and 37 °c, t1904 m could increase […]


Molecular Characterization of a Novel Germline VHL Mutation by Extensive In Silico Analysis in an Indian Family with Von Hippel Lindau Disease

PMCID: 4812357
PMID: 27069690
DOI: 10.1155/2016/9872594

[…] from tolerant (sift) [], polymorphism phenotyping 2 (polyphen 2) [], screening for non-acceptable polymorphisms (snap) [], provean (protein variation effect analyzer) [], mupro [], istable [] mustab [], and i-mutant suite []. these methods utilize sequence homology (conservation), amino acid physicochemical and structural properties to predict variant's effect on protein function […]


Molecular findings of Colombian patients with type VI mucopolysaccharidosis (Maroteaux–Lamy syndrome)

PMCID: 4733218
PMID: 26909334
DOI: 10.1016/j.mgene.2015.12.004

[…] the defects in the protein variant were performed using the following bioinformatic tools: polyphen-2 ( (), mutationtaster ( (), mustab ( (), snps&go ( (), and provean ( (). novel mutated amino acids […]


Computational and Experimental Approaches to Reveal the Effects of Single Nucleotide Polymorphisms with Respect to Disease Diagnostics

PMCID: 4100115
PMID: 24886813
DOI: 10.3390/ijms15069670

[…] and the structural features affected by the mutation. other tools based on similar approaches include mutation taster [], ls–snp/pdb [], snpeffect [], predicting protein mutant stability change (mustab) [,], mupro [], mutpred [], snpdbe [], netdiseasesnp [], hope [] and snps3d []., in addition to, or in combination with evolutionary and sequence-based methods, several machine learning […]


Feature based multiple models improve classification of mutation induced stability changes

PMCID: 4083411
PMID: 25057118
DOI: 10.1186/1471-2164-15-S4-S6

[…] test set to see if the feature selection did not result in features which do not generalise well. using the s238 data set, we compared the performance of three currently available methods (mupro [], mustab [], and i-mutant2.0 []), our previous work (ease-aa []), the single-model method (ease-aa2), and the three methods with multiple models (ease-asa, ease-ss, and ease-mm). table summarises […]

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MuStab institution(s)
Department of Genetics and Biochemistry, Clemson University, Clemson, SC, USA; J.C. Self Research Institute of Human Genetics, Greenwood Genetic Center, Greenwood, SC, USA
MuStab funding source(s)
Supported by the CSREES/USDA, under project number SC1700355.

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