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Associated diseases

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MuStab specifications

Information


Unique identifier OMICS_08590
Name MuStab
Interface Web user interface
Restrictions to use None
Input data An amino acid sequence.
Input format FASTA
Output data The information about the query sequence and amino acid substitution, the prediction result, and the prediction confidence.
Computer skills Basic
Stability No
Maintained No

Maintainer


This tool is not available anymore.

Publication for MuStab

MuStab in publications

 (8)
PMCID: 5490637
PMID: 28290225
DOI: 10.1080/14760584.2017.1306441

[…] data, but in general are rather runtime-intensive. thus, they are restricted to investigate only a comparably small number of mutations. machine learning methods are either sequence based (e.g. mustab, iptree-stab, inps) or structure based (e.g. inps3d, mcsm, popmusic). they provide good prediction accuracy and in general are faster than the aforementioned methods. hence, they are better […]

PMCID: 4819269
PMID: 27047549
DOI: 10.1186/s13223-016-0120-6

[…] for threonine (acg) was highly conserved, with the third varied greatly (fig. b). this mutation was predicted to be possibly damaging with a score of 0.469 by polyphen-2. the web-based software, mustab (predicting mutant protein stability change) was applied to predict if the snp could influence the stability of helz2. under the condition of ph 7.0 and 37 °c, t1904 m could increase […]

PMCID: 4812357
PMID: 27069690
DOI: 10.1155/2016/9872594

[…] from tolerant (sift) [], polymorphism phenotyping 2 (polyphen 2) [], screening for non-acceptable polymorphisms (snap) [], provean (protein variation effect analyzer) [], mupro [], istable [] mustab [], and i-mutant suite []. these methods utilize sequence homology (conservation), amino acid physicochemical and structural properties to predict variant's effect on protein function […]

PMCID: 4733218
PMID: 26909334
DOI: 10.1016/j.mgene.2015.12.004

[…] the defects in the protein variant were performed using the following bioinformatic tools: polyphen-2 (http://genetics.bwh.harvard.edu/pph2/) (), mutationtaster (http://www.mutationtaster.org/) (), mustab (http://bioinfo.ggc.org/mustab/) (), snps&go (http://snps-and-go.biocomp.unibo.it/snps-and-go/) (), and provean (http://provean.jcvi.org/index.php) (). novel mutated amino acids […]

PMCID: 4100115
PMID: 24886813
DOI: 10.3390/ijms15069670

[…] and the structural features affected by the mutation. other tools based on similar approaches include mutation taster [], ls–snp/pdb [], snpeffect [], predicting protein mutant stability change (mustab) [,], mupro [], mutpred [], snpdbe [], netdiseasesnp [], hope [] and snps3d []., in addition to, or in combination with evolutionary and sequence-based methods, several machine learning […]


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MuStab institution(s)
Department of Genetics and Biochemistry, Clemson University, Clemson, SC, USA; J.C. Self Research Institute of Human Genetics, Greenwood Genetic Center, Greenwood, SC, USA
MuStab funding source(s)
Supported by the CSREES/USDA, under project number SC1700355.

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