MutSig specifications

Unique identifier:
Alternative name:
Command line interface
Input data:
A list of mutations (and indels) from a set of samples (patients) that were subjected to DNA sequencing, a coverage file that contains information about the sequencing coverage achieved for each gene and patient/tumor, a covariate file that contains the genomic covariate data for each gene.
Output data:
A tab-delimited report of significant mutations, listed in descending order from most significant to least significant.
Operating system:
Computer skills:
Mutation Significance
Software type:
Restrictions to use:
Input format:
Output format:
Programming languages:


tutorial arrow
Upload and version your source code
Get a DOI for each update to improve tool traceability. Archive your releases so the community can easily visualize progress on your work.
Facilitate your tool traceability
Sign up for free to upload your code and get a DOI

No versioning.


tutorial arrow
Communicate with other users
Participate in the forum to get support for using tools. Ask questions about technical specifications.
Take part in the discussion
Sign up for free to ask question and share your advices

No open topic.


tutorial arrow
Promote your skills
Define all the tasks you managed and assign your profile the appropriate badges. Become an active member.
Promote your work
Sign up for free to badge your contributorship



The Broad Institute of MIT and Harvard, Cambridge, MA, USA; Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Instituto Nacional de Medicina Genómica, Mexico City, Mexico; Yale Cancer Center, Department of Hematology, New Haven, CT, USA; Massachusetts General Hospital, Boston, MA, USA; Brigham and Women’s Hospital, Boston, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA; Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel; Boston Children’s Hospital, Boston, MA, USA; Children’s Hospital, Philadelphia, PA, USA; Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, DHHS, Durham, NC, USA; Department of Pediatric Oncology, Hospital Sant Joan de Déu, Barcelona, Spain; Genome Sciences, University of Washington, Seattle, WA, USA

Funding source(s)

This work was supported as part of The Cancer Genome Atlas (TCGA), a project of the National Cancer Institute (NCI) and National Human Genome Research Institute (NHGRI) and as part of the Slim Initiative for Genomic Medicine (SIGMA), a joint U.S.-Mexico project founded by the Carlos Slim Health Institute, and the Intramural Research Program of the NIEHS (NIH, DHHS) project ES065073.

User review

tutorial arrow
Vote up tools and offer feedback
Give value to tools and make your expertise visible
Give your feedback on this tool
Sign up for free to join and share with the community

0 user reviews

star_border star_border star_border star_border star_border
star star star star star

0 user reviews

star_border star_border star_border star_border star_border
star star star star star

No review has been posted.

Related Tools