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MuSiC | Identifying mutational significance in cancer genomes

A set of tools aimed at determining the significance of somatic mutations discovered within a given cohort of cancer samples, incorporating the cohort's alignment data, variant lists and any relevant clinical data. The development of MuSiC was motivated by the rapidly expanding numbers of mutation data sets from a wide variety of tumor types. It is imperative during post-discovery analysis to separate the significant, or “driver,” mutations from the passenger mutations to more accurately pinpoint the key genes and pathways critical for disease initiation and progression. MuSiC is designed precisely to streamline this process into an easily accessible high-throughput software exercise.

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MuSiC classification

MuSiC specifications

Unique identifier:
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Mutational Significance In Cancer
Command line interface
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MuSiC distribution


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MuSiC support


  • Li Ding <>


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The Genome Institute, Washington University, St Louis, MO, USA

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