MutPred protocols

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description
MutPred computational protocol

MutPred specifications

Information


Unique identifier OMICS_00154
Name MutPred
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes

Taxon


  • Primates
    • Homo sapiens

Publication for MutPred

MutPred IN pipelines

 (4)
2018
PMCID: 5827201
PMID: 29483551
DOI: 10.1038/s41598-018-21844-6

[…] a16183c, t16519c), which are polymorphisms that are not haplogroup associated but occur very frequently in the general population39. the remaining constitutional variants were considered private., mutpred17 was used to predict the pathogenicity and functional consequences of non-synonymous variants present within the set of private constitutional variants and somatic mutations. the genbank […]

2017
PMCID: 5461698
PMID: 28587604
DOI: 10.1186/s12881-017-0422-7

[…] another 10 amino acid substitutions were classified as tolerated (subspec score range: from−2.72126 to−0.69172), and the remaining 12 amino acid substitutions did not have subspec scores (table 2)., mutpred predicts molecular causes of disease or deleterious amino acid substitution. a total of 30 nssnps had p-values > 0.5, which were considered to be functional [84] (mutpred pdeleterious […]

2017
PMCID: 5461698
PMID: 28587604
DOI: 10.1186/s12881-017-0422-7

[…] scores (table 2)., mutpred predicts molecular causes of disease or deleterious amino acid substitution. a total of 30 nssnps had p-values > 0.5, which were considered to be functional [84] (mutpred pdeleterious range: 0.566-0.981), which included 6 kcnj11 missense snps (v59m, i182v, r192h, r201h, e227k, l270v), 23 abcc8 missense snps (g7r, n24k, f27s, n72s, r74w, a116p, e128k, f132l, […]

2013
PMCID: 3823931
PMID: 24244370
DOI: 10.1371/journal.pone.0078823

[…] interface. additional information on the location of cpg islands was downloaded from the ucsc genome browser and incorporated into our in-house code. pathogenicity scores were attained from mutpred [15]. variable distributions or count data were tested between samples, or variant type, using an appropriate significance test (wilcoxon and chi-squared or fisher’s exact respectively) […]

MutPred institution(s)
School of Informatics and Computing, Indiana University, Bloomington, IN, Novato, CA, USA
MutPred funding source(s)
National Institutes of Health R01LM009722; National Science Foundation DBI-0644017

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