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N-Ace specifications

Information


Unique identifier OMICS_10770
Name N-Ace
Interface Web user interface
Restrictions to use None
Input data Protein sequence
Input format FASTA
Computer skills Basic
Stability No
Maintained Yes

Maintainer


  • person_outline Po-Chiang Hsu

Publication for N-Ace

N-Ace citations

 (12)
call_split

N domain of angiotensin converting enzyme hydrolyzes human and rat amyloid β(1 16) peptides as arginine specific endopeptidase potentially enhancing risk of Alzheimer’s disease

2018
Sci Rep
PMCID: 5762728
PMID: 29321566
DOI: 10.1038/s41598-017-18567-5
call_split See protocol

[…] The N-domain and C-domains of bovine ACE (N-ACE and C-ACE), homogenous according to sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), were provided by Dr P.V. Binevski (Moscow State University, Russia). Enzymatic activitie […]

library_books

Protein post translational modifications: In silico prediction tools and molecular modeling

2017
Comput Struct Biotechnol J
PMCID: 5397102
PMID: 28458782
DOI: 10.1016/j.csbj.2017.03.004

[…] ere considered during the prediction process. It also allows predicting acetylated sites not only for lysines, but also for glycine, methionine serine and threonine residues. This is actually done by N-Ace , where physiochemical properties (e.g., non-bonded energy, absolute entropy) and solvent accessibility were included in the original prediction code.The status of lysine acetylation can also be […]

library_books

Crystal structure of a peptidyl‐dipeptidase K‐26‐DCP from Actinomycete in complex with its natural inhibitor

2016
PMCID: 5157764
PMID: 27754586
DOI: 10.1111/febs.13928

[…] K‐26 was shown to bind to both N‐ACE and C‐ACE, and the Drosophila melanogaster homologue AnCE (PDBs 4BZS, 4BZR and 2XHM respectively) in a location whereby it solely occupies the ‘non‐prime’ side of the catalytic channel , , in co […]

library_books

Structural basis of Ac SDKP hydrolysis by Angiotensin I converting enzyme

2015
Sci Rep
PMCID: 4585900
PMID: 26403559
DOI: 10.1038/srep13742

[…] s compared to the C-domain enzyme residue Val518. In the P1′ pocket, our structure with Lys-Pro shows that the dipeptide’s ε-amino group can interact with Thr358 which is also not conserved in C-domain ACE (Val380). It should be added that water molecules are expected to play a significant role in peptide binding, as illustrated by several water-mediated bonds in the crystal structures presented h […]

library_books

N Acetyl Cysteine in the Treatment of Obsessive Compulsive and Related Disorders: A Systematic Review

2015
PMCID: 4423164
PMID: 25912534
DOI: 10.9758/cpn.2015.13.1.12

[…] OR “skin picking” OR “nail biting” OR “impulse control disorder” OR “obsessive compulsive disorder” OR “OCD” OR “OCRD” OR “obsessions” OR “compulsions” OR “obsessive compulsive related disorder” AND “N-ace-tylcysteine” OR “n-acetyl-cysteine” OR “nacetylcysteine” OR “cystine” OR “n acetylcysteine” OR “n acetyl cysteine” OR “N-acetyl-L-cysteine”. Academics and researchers with known involvement in N […]

library_books

An Intelligent System for Identifying Acetylated Lysine on Histones and Nonhistone Proteins

2014
Biomed Res Int
PMCID: 4132336
PMID: 25147802
DOI: 10.1155/2014/528650

[…] redictor for human lysine acetylation from short linear motifs catalyzed by acetyltransferases and captured linear/nonlinear correlation among residues around target lysine residues []. Another tool, N-Ace, uses data clustering with specific subcellular localization (e.g., histones, nucleus, cytoplasm, membrane, and mitochondrion) to distinguish the potential substrates catalyzed by different loca […]

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N-Ace institution(s)
Department of Computer Science and Engineering, Yuan Ze University, Taiwan; Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Taiwan; Institute of Tropical Plant Sciences, National Cheng Kung University, Taiwan; Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, Taiwan; Department of Biological Science and Technology, National Chiao Tung University, Taiwan
N-Ace funding source(s)
National Science Council of the Republic of China, Taiwan (Grant Numbers: NSC 98-2627-B-009-005, NSC 98-2311-B-009-004-MY3, NSC 99-2320-B-155-001)

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