N-Ace specifications


Unique identifier OMICS_10770
Name N-Ace
Interface Web user interface
Restrictions to use None
Input data Protein sequence
Input format FASTA
Computer skills Basic
Stability No
Maintained Yes


  • person_outline Po-Chiang Hsu <>

Publication for N-Ace

N-Ace in publications

PMCID: 5762728
PMID: 29321566
DOI: 10.1038/s41598-017-18567-5

[…] modelling we have tested a set of peptides corresponding to mbds of aβ and rataβ to get insights on the interactions between ace and these aβ species. it has been shown that the n-domain of ace (n-ace) acts as an arginine specific endopeptidase on the aβ and rataβ mbds with c-amidated termini, thus assuming that full-length aβ and rataβ can be hydrolyzed by n-ace in the same endopeptidase […]

PMCID: 4585900
PMID: 26403559
DOI: 10.1038/srep13742

[…] intermediate is likely stabilised by tyr501. as mentioned previously, chloride has an important effect on ace activity which is also substrate-dependent in the c-domain. the function of chloride in n-ace is less understood, but it is unlikely to affect substrate specificity. however, a role for the direct involvement of the conserved chloride-coordinating arg500 should not be excluded […]

PMCID: 4132336
PMID: 25147802
DOI: 10.1155/2014/528650

[…] for human lysine acetylation from short linear motifs catalyzed by acetyltransferases and captured linear/nonlinear correlation among residues around target lysine residues []. another tool, n-ace, uses data clustering with specific subcellular localization (e.g., histones, nucleus, cytoplasm, membrane, and mitochondrion) to distinguish the potential substrates catalyzed by different […]

PMCID: 4104576
PMID: 25042424
DOI: 10.1038/srep05765

[…] approach, ensemble-pail, which implemented an ensemble support vector machine (svm) classifier with encoded features based on positional weight matrices (pwms). a two-stage svm-based classifier, n-ace, proposed by lee et al., was applied to identify protein acetylation sites based on features combining the physicochemical properties of proteins with accessible surface area. suo et al. […]

PMCID: 3278826
PMID: 22372765
DOI: 10.1186/1471-2105-12-S13-S10

[…] the removal of homologous sequences in the positive data is done by using a window size of 2n+1 centered on the carboxylation site. with reference to the method of homology reduction in n-ace [], two carboxylated proteins having more than 30% sequence similarity are regarded as homologous proteins. then, for every two homologous protein sequences, bl2seq [] is applied to re-align […]

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N-Ace institution(s)
Department of Computer Science and Engineering, Yuan Ze University, Taiwan; Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Taiwan; Institute of Tropical Plant Sciences, National Cheng Kung University, Taiwan; Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, Taiwan; Department of Biological Science and Technology, National Chiao Tung University, Taiwan
N-Ace funding source(s)
National Science Council of the Republic of China, Taiwan (Grant Numbers: NSC 98-2627-B-009-005, NSC 98-2311-B-009-004-MY3, NSC 99-2320-B-155-001)

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