N-myristoylation site databases | Post-translational modification data analysis
One of the most critical modifications affecting the N-terminus of proteins is N-myristoylation. This irreversible modification affects the membrane-binding properties of crucial proteins involved in signal transduction cascades.
Myristoylation is a common lipid modification of proteins in eukaryotes and their viruses as well as some bacteria and essential for the function of several important proteins. The large-scale cross-genome analyses, available as MYRbase, show that the functional spectrum of myristoylated proteins is currently largely underestimated.