N-myristoylation site detection software tools | Post-translational modification data analysis
N-myristoylation is a post-translational modification of proteins where a myristoyl group is attached to an N-terminal glycine residue. This lipidation event plays a role in protein-protein and protein-lipid interaction as well as membrane targeting. This process is used by several prokaryotic, eukaryotic and fungal organisms and their viruses, and thus plays an important role in health and disease. N-myristoylation detection tools scan protein sequences to predict myristoylation sites.
Predicts N-terminal myristoylation of proteins by neural networks. We used ensembles of neural networks, in order to learn to discriminate positive and negative sequences for myristoylation. Note that the neural network predictor has not been trained to predict myristoylation of internal glycines. The score S of our predictor is based on the average responses of 25 artificial neural networks.
Recognizes glycine N-myristoylation sites (at the N-terminus and for fragments after processing) of higher eukaryotes (including their viruses) and fungi. The PTS1 signal predictor finds proteins with a C-terminus appropriate for peroxisomal import (for metazoa and fungi).
Predicts potential lipid modification sites for a given interesting protein sequences. GPS-LIPID is a comprehensive predictor for multiple protein lipid modification sites. It can be easily accessed through either standalone package or interactive web server. This method adopts the ALC-PSO strategy to prevent premature convergence and maintain fast training feature. It assists the investigation of lipid modification for the research community.
Searches for matches to a plant-specific target sequence for N-terminal myristoylation. The search uses a profile hidden Markov model, 19 residues long, that has been trained on known and probably N-myristoylated plant protein sequences. For each query sequence, the program reports the highest scoring match, plus any additional matches with scores greater than the threshold cutoff value (0.55). A P-value (log probability) is calculated for each match based on score frequencies on all predicted proteins in the Arabidopsis thaliana genome.
Extracts and organizes comprehensive post-translational modifications (PTMs) information from literature in PubMed. MPTM provides literature mining service for hydroxylation, myristoylation. It extracts basic PTM information including substrates and modification sites and also comprehensive PTM-related information such as enzymes, Gene Ontology (GO) terms, organisms, diseases and crosstalk from literature.