N3 pipeline

N3 specifications


Unique identifier OMICS_27484
Name N3
Alternative name Non-parametric Non-uniform intensity Normalization
Software type Application/Script
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Programming languages C, C++
Computer skills Advanced
Version 1.12.10
Stability Stable
Maintained Yes



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  • person_outline John Sled <>

Additional information


Publication for Non-parametric Non-uniform intensity Normalization

N3 IN pipeline

PMCID: 5775193
PMID: 29352231
DOI: 10.1038/s41598-018-19420-z

[…] was applied to all mr data to minimize the field inhomogeneity effects and artificial low-frequency intensity variations across the images28. the n4 bias correction is an improved version of the non-parametric non-uniform intensity normalization (n3) algorithm with an enhanced b-spline least squares fitting routine (which includes multi-resolution capabilities) and a modified optimization […]

N3 institution(s)
Department of Biomedical Engineering, McGill University, Montréal, QC, Canada
N3 funding source(s)
Supported by the Natural Sciences and Engineering Research Council of Canada.

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