Provides profiles of elementary functional loops (EFLs) involved in binding of nucleotide-containing ligands. Each EFL in form of a PSSM (position-specific scoring matrix) profile is complemented with the information on SCOP entities, structural representatives in the PDB, and interactions between EFLs residues and corresponding parts of ligands. A comprehensive set of 249 profiles covers interactions with 24 nucleotide-containing ligands, cofactors and vitamins. You can explore profile interactions with different ligands and their chemical moieties. It is also possible to search for EFLs involved into binding of nucleotide-containing ligands given the protein sequence of interest.
Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Matrix, Singapore; Computational Biology Unit, Department of Informatics, University of Bergen, Norway; Department of Biological Sciences (DBS), National University of Singapore (NUS), Singapore