Main logo
tutorial arrow
Create your own tool library
Bookmark tools and put favorites into folders to find them easily.

Negative GO Annotations NegGOA


Selects negative examples of GO annotations using ontology structure. NegGOA takes advantage of the ontology structure, available annotations and potentiality of additional annotations of a protein to choose negative examples of the protein. We compare this tool with other negative examples selection algorithms and find that NegGOA produces much fewer false negatives than them. We incorporate the selected negative examples into an efficient function prediction model to predict the functions of proteins in Yeast, Human, Mouse and Fly. It also demonstrates improved accuracy than these comparing algorithms across various evaluation metrics. In addition, NegGOA is less suffered from incomplete annotations of proteins than these comparing methods.

User report

tutorial arrow
Vote up tools and offer feedback
Give value to tools and make your expertise visible
Give your feedback on this tool
Sign up for free to join and share with the community

0 user reviews

0 user reviews

No review has been posted.

NegGOA forum

tutorial arrow
Communicate with other users
Participate in the forum to get support for using tools. Ask questions about technical specifications.
Take part in the discussion
Sign up for free to ask question and share your advices

No open topic.

NegGOA classification

  • Animals
    • Drosophila melanogaster
    • Homo sapiens
    • Mus musculus
  • Fungi
    • Saccharomyces cerevisiae

NegGOA specifications

Software type:
Restrictions to use:
Academic or non-commercial use
Output data:
Negative annotations of a protein
Programming languages:
Computer skills:
Command line interface
Input data:
Ontology structure, available annotations and potentiality of additional annotations of a protein
Operating system:
Unix/Linux, Mac OS, Windows
Artistic License version 2.0

NegGOA distribution


tutorial arrow
Upload and version your source code
Get a DOI for each update to improve tool traceability. Archive your releases so the community can easily visualize progress on your work.
Facilitate your tool traceability
Sign up for free to upload your code and get a DOI

No versioning.


NegGOA support


  • Guoxian Yu <>


tutorial arrow
Promote your skills
Define all the tasks you managed and assign your profile the appropriate badges. Become an active member.
Promote your work
Sign up for free to badge your contributorship



College of Computer and Information Science, Southwest University, Chongqing, China; Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun, China

Funding source(s)

Natural Science Foundation of China (No. 61402378); Natural Science Foundation of CQ CSTC (No. cstc2014jcyjA40031); Fundamental Research Funds for the Central Universities of China (2362015XK07, XDJK2016B009 and XDJK2016D021)

Link to literature

By using OMICtools you acknowledge that you have read and accepted the terms of the end user license agreement.