Furnishes reliable negative interaction datasets. Negatome contains more than 800 structure-based non-interacting pairs (NIP). It was constructed by manual curation of literature and by investigating protein complexes from the Protein Data bank (PDB). This database is useful to assess derived experimental interactions. It employs an advanced text mining procedure, Excerbt, to add potential non-interactions to the collection.
Institute for Bioinformatics and Systems Biology/MIPS, HMGU - German Research Center for Environmental Health, Neuherberg, Germany; Clueda AG, Munich, Germany; Department of Genome Oriented Bioinformatics, Technische Universitaet Muenchen Wissenschaftszentrum Weihenstephan, Freising, Germany
Negatome funding source(s)
Supported by DFG International Research Training Group ‘Regulation and Evolution of Cellular Systems’ [GRK 1563]; the Joint Technology Platform within the Helmholtz Alliance for Systems Biology and the Federal Ministry of Education, Science, Research and Technology [NGFN: 01GR0451, SysMBo, FKZ: 0315494A].