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nFuse | Discovery of complex genomic rearrangements in cancer using HTS

Allows users to discover fusion transcripts and underlying complex genomic rearrangements (CGRs) in breast cancer cell line HCC1954 and a primary prostate tumor sample 963. nFuse identifies two types of CGRs: closed chains of breakage and rejoining (CCBRs) and polyfusions/complex breakpoints. This tool can be used for the detection of the single breakpoints underlying fusion transcripts caused by more simple rearrangements.

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nFuse classification

nFuse specifications

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GNU General Public License version 3.0

nFuse distribution


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nFuse support



  • Cenk Sahinalp <>
  • Andrew McPherson <>


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School of Computing Science, Simon Fraser University, Vancouver, BC, Canada; Vancouver Prostate Centre, Vancouver, BC, Canada; Department of Molecular Oncology, BC Cancer Research Centre, Vancouver, BC, Canada

Funding source(s)

Supported by the Natural Sciences and Engineering Research Council of Canada (NSERC), Bioinformatics for Combating Infectious Diseases (BCID) grants, NSERC Alexander Graham Bell Canada Graduate Scholarships (CGS-D), and the CIHR/MSFHR Strategic Training Program in Bioinformatics.

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