An accurate MHC binders prediction method for the large number of class I MHC alleles. nHLAPred allows to identify the promiscuous MHC class I binders (peptides that can bind to large number of alleles) having proteasomal cleavage site at C-terminus. This leads to identification of MHC class I restricted T cell epitopes in an antigen sequence. The server is partitioned in two parts ComPred and ANNpred. In ComPred part the prediction is based on the hybrid approach of Quantitative matrices and artificial neural network. In ANNPred the prediction is solely based on artificial neural network.