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Array-based comparative genomic hybridization (aCGH) is a powerful tool to detect genomic imbalances in the human genome. The analysis of aCGH data sets has revealed the existence of a widespread technical artifact termed as 'waves', characterized by an undulating data profile along the chromosome.
(Lepretre et al., 2010) Waved aCGH: to smooth or not to smooth. Nucleic Acids Res.