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NormaCurve

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Allows to simultaneously quantify and normalize Reverse Phase Protein Arrays (RPPAs). NormaCurve is a normalization model that considers the two control arrays ctrl and sypro, as well as the two spatial effects Row and Column. The model, validated by cross-validation, allows the correction of spatial effects and corrects for differences in total amount of spotted proteins. It does not require a minimum amount of antibodies to be powerful and it is not affected by a bias in the chosen antibodies.

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NormaCurve classification

NormaCurve specifications

Software type:
Package/Module
Restrictions to use:
None
Computer skills:
Advanced
Stability:
Stable
Interface:
Command line interface
Operating system:
Unix/Linux
Version:
1.0.0
Maintained:
Yes

NormaCurve distribution

versioning

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No versioning.

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NormaCurve support

Maintainer

  • Leanne de Koning <>

Credits

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Publications

Institution(s)

Institut Curie, Paris, France; Department of Translational Research, Institut Curie, Paris, France; INSERM, U900, Paris, France; Mines ParisTech, Fontainebleau, France; CNRS UMR144, Paris, France

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