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NPD specifications


Unique identifier OMICS_19175
Name NPD
Alternative name Nuclear Protein Database
Restrictions to use None
Database management system MySQL
Community driven No
Data access Browse
User data submission Not allowed
Version 2.0
Maintained Yes


  • person_outline Wendy Bickmore

Publication for Nuclear Protein Database

NPD citations


Compartmentalization and Functionality of Nuclear Disorder: Intrinsic Disorder and Protein Protein Interactions in Intra Nuclear Compartments

Int J Mol Sci
PMCID: 4730271
PMID: 26712748
DOI: 10.3390/ijms17010024

[…] y comprehensive PPI network. We collected nuclear proteins from the intra-nuclear compartment protein database Nsort/DB []. This comprehensive database aggregates data from multiple sources including Nuclear Protein Database (NPD) [], Nuclear Proteome Database (NOPdb) [], Nuclear Matrix Protein Database (NMPdb) [], UniProt [] and Human Protein Reference Database (HPRD) []. The complete nuclear pro […]


Nucleolar Localization of GLTSCR2/PICT 1 Is Mediated by Multiple Unique Nucleolar Localization Sequences

PLoS One
PMCID: 3264635
PMID: 22292050
DOI: 10.1371/journal.pone.0030825

[…] that PICT-1 is localized in the nucleolus and predicted the amino acids required for this targeting . We performed a more detailed examination of PICT-1's amino acid sequence using PSORT II, ELM and Nuclear Protein Database tools, which led us to refine our prediction as depicted schematically in : three bipartite NLSs, spanning amino acids 101–117, 387/9/90–405/6 and 447–464/5; and three monopar […]


Amino acid classification based spectrum kernel fusion for protein subnuclear localization

BMC Bioinformatics
PMCID: 3009488
PMID: 20122188
DOI: 10.1186/1471-2105-11-S1-S17

[…] ations is unbalanced, the largest Nucleolus has 307 proteins and the smallest Nuclear PML body has only 13 proteins. The dataset has total 714 proteins. The Lei benchmark dataset [] is collected from Nuclear Protein Database [], chiefly from human and mouse, and divides cell nucleus into 6 subnuclear locations and totals up to 504 proteins. This dataset is also unbalanced. […]


An SVM based system for predicting protein subnuclear localizations

BMC Bioinformatics
PMCID: 1325059
PMID: 16336650
DOI: 10.1186/1471-2105-6-291

[…] nucleolar proteins are continually exchanging between the nucleoplasm and the nucleolus. Proteomic studies have also highlighted the dynamic nature of the nucleolar proteome [].Employing the database Nuclear Protein Database (NPD) developed by Dellaire, Farrall and Bickmore [], Bickmore and Sutherland [] recently addressed the characteristics of the primary sequences of nuclear proteins, such as t […]


The two tempos of nuclear pore complex evolution: highly adapting proteins in an ancient frozen structure

Genome Biol
PMCID: 1257468
PMID: 16207356
DOI: 10.1186/gb-2005-6-10-r85

[…] Homologous sequences of all the identified nucleoporins in vertebrates and in fungi [,,,] (completed by the list of proteins published in the Nuclear Protein Database []), of proteins involved in the NPC anchoring system [,,], and of several important protein partners in and around the nuclear envelope (Table ) were retrieved from the Natio […]


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NPD institution(s)
MRC Human Genetics Unit, Crewe Road, Edinburgh, UK; The Hospitalfor Sick Children, Program in Cell Biology, Toronto, ON, Canada
NPD funding source(s)
Supported by the Medical Research Council (UK), the James S. McDonnell Foundation and the Canadian Institutes of Health Research (CIHR).

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