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NRPS-PKS specifications


Unique identifier OMICS_20951
Restrictions to use None
Community driven No
Data access Browse
User data submission Not allowed
Maintained Yes


  • person_outline Debasisa Mohanty

Publication for NRPS-PKS

NRPS-PKS citations


Biosynthesis of fragin is controlled by a novel quorum sensing signal

Nat Commun
PMCID: 5878181
PMID: 29602945
DOI: 10.1038/s41467-018-03690-2

[…] Protein domains were analyzed with the NRPS/PKS analysis tool, NaPDoS (Natural Product Domain Seeker) and the InterProSCan 5 online tool.The architecture search mode of the MultiGeneBlast software was used to identify gene clusters similar […]


Draft Genome Sequence of the Antimycin Producing Bacterium Streptomyces sp. Strain SM8, Isolated from the Marine Sponge Haliclona simulans

Genome Announc
PMCID: 5786686
PMID: 29371360
DOI: 10.1128/genomeA.01535-17

[…] NAs ().Analysis for the prediction of secondary metabolite gene clusters using antiSMASH v4.0.2 identified several gene clusters encoding polyketide synthases (PKS), nonribosomal peptide synthetases (NRPS), PKS/NRPS hybrids, terpene biosynthesis, and siderophores (). The complete gene cluster for the biosynthesis of antimycin—a compound which was previously identified by mass spectrometry analysis […]


The insect pathogenic bacterium Xenorhabdus innexi has attenuated virulence in multiple insect model hosts yet encodes a potent mosquitocidal toxin

BMC Genomics
PMCID: 5709968
PMID: 29191166
DOI: 10.1186/s12864-017-4311-4

[…] diverse activities, including toxicity against target organisms []. To begin to assess the ability of X. innexi to produce such compounds we computationally screened for clusters predicted to encode NRPS, PKS, or hybrids. Our initial screening identified one PKS, 12 NRPS and three NRPS-PKS hybrid gene clusters (Table ). The hybrid genes were further examined by analyzing their amino acid sequence […]


Chromosome level assembly and secondary metabolite potential of the parasitic fungus Cordyceps militaris

BMC Genomics
PMCID: 5702197
PMID: 29178836
DOI: 10.1186/s12864-017-4307-0

[…] homology with gene clusters from other organisms that produce characterized natural products [, ].It seems that a logical product of cluster III-1 could be a 2-pyridone alkaloid molecule. The hybrid NRPS-PKS central to this cluster (A9K55_001190) is similar to the NRPS-PKS responsible for the production of desmethylbassianin (70% identity) and tenellin (67% identity) from Beauveria bassiana and f […]


Large Scale Bioinformatics Analysis of Bacillus Genomes Uncovers Conserved Roles of Natural Products in Bacterial Physiology

PMCID: 5686519
PMID: 29152584
DOI: 10.1128/mSystems.00040-17

[…] to describe the relatedness of each DBSCAN cluster to all other DBSCAN clusters in our MGB database. We sorted the resulting DBSCAN clusters by the class of natural product that they contained (e.g., NRPS, PKS, etc.) based on antiSMASH’s assignments. We then used Cytoscape () to build network maps that allowed the relationships between the DBSCAN clusters to be visualized. These network maps provi […]


Comparative Genome Analysis Reveals Adaptation to the Ectophytic Lifestyle of Sooty Blotch and Flyspeck Fungi

Genome Biol Evol
PMCID: 5737583
PMID: 29126189
DOI: 10.1093/gbe/evx229

[…] orters were identified using the transporter prediction server TransportTP (e value < 1e-05) (). Prediction of genes coding for nonribosomal peptide synthase (NRPS), polyketide synthase (PKS), hybrid NRPS-PKS, dimethylallyl tryptophan synthase (DMATS), and terpene cyclase (TC) was performed using the programs SMURF () and antiSMASH 2.0 () in combination (union). Identification of carbohydrate-acti […]


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NRPS-PKS institution(s)
National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India
NRPS-PKS funding source(s)
Supported by grants to the National Institute of Immunology from the Department of Biotechnology, Government of India.

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