NRPS-PKS statistics

Tool stats & trends

Looking to identify usage trends or leading experts?

Protocols

NRPS-PKS specifications

Information


Unique identifier OMICS_20951
Name NRPS-PKS
Restrictions to use None
Community driven No
Data access Browse
User data submission Not allowed
Maintained Yes

Maintainer


  • person_outline Debasisa Mohanty

Publication for NRPS-PKS

NRPS-PKS citations

 (86)
library_books

Biosynthesis of fragin is controlled by a novel quorum sensing signal

2018
Nat Commun
PMCID: 5878181
PMID: 29602945
DOI: 10.1038/s41467-018-03690-2

[…] Protein domains were analyzed with the NRPS/PKS analysis tool, NaPDoS (Natural Product Domain Seeker) and the InterProSCan 5 online tool.The architecture search mode of the MultiGeneBlast software was used to identify gene clusters similar […]

library_books

Draft Genome Sequence of the Antimycin Producing Bacterium Streptomyces sp. Strain SM8, Isolated from the Marine Sponge Haliclona simulans

2018
Genome Announc
PMCID: 5786686
PMID: 29371360
DOI: 10.1128/genomeA.01535-17

[…] NAs ().Analysis for the prediction of secondary metabolite gene clusters using antiSMASH v4.0.2 identified several gene clusters encoding polyketide synthases (PKS), nonribosomal peptide synthetases (NRPS), PKS/NRPS hybrids, terpene biosynthesis, and siderophores (). The complete gene cluster for the biosynthesis of antimycin—a compound which was previously identified by mass spectrometry analysis […]

library_books

The insect pathogenic bacterium Xenorhabdus innexi has attenuated virulence in multiple insect model hosts yet encodes a potent mosquitocidal toxin

2017
BMC Genomics
PMCID: 5709968
PMID: 29191166
DOI: 10.1186/s12864-017-4311-4

[…] diverse activities, including toxicity against target organisms []. To begin to assess the ability of X. innexi to produce such compounds we computationally screened for clusters predicted to encode NRPS, PKS, or hybrids. Our initial screening identified one PKS, 12 NRPS and three NRPS-PKS hybrid gene clusters (Table ). The hybrid genes were further examined by analyzing their amino acid sequence […]

library_books

Chromosome level assembly and secondary metabolite potential of the parasitic fungus Cordyceps militaris

2017
BMC Genomics
PMCID: 5702197
PMID: 29178836
DOI: 10.1186/s12864-017-4307-0

[…] homology with gene clusters from other organisms that produce characterized natural products [, ].It seems that a logical product of cluster III-1 could be a 2-pyridone alkaloid molecule. The hybrid NRPS-PKS central to this cluster (A9K55_001190) is similar to the NRPS-PKS responsible for the production of desmethylbassianin (70% identity) and tenellin (67% identity) from Beauveria bassiana and f […]

library_books

Large Scale Bioinformatics Analysis of Bacillus Genomes Uncovers Conserved Roles of Natural Products in Bacterial Physiology

2017
mSystems
PMCID: 5686519
PMID: 29152584
DOI: 10.1128/mSystems.00040-17

[…] to describe the relatedness of each DBSCAN cluster to all other DBSCAN clusters in our MGB database. We sorted the resulting DBSCAN clusters by the class of natural product that they contained (e.g., NRPS, PKS, etc.) based on antiSMASH’s assignments. We then used Cytoscape () to build network maps that allowed the relationships between the DBSCAN clusters to be visualized. These network maps provi […]

library_books

Comparative Genome Analysis Reveals Adaptation to the Ectophytic Lifestyle of Sooty Blotch and Flyspeck Fungi

2017
Genome Biol Evol
PMCID: 5737583
PMID: 29126189
DOI: 10.1093/gbe/evx229

[…] orters were identified using the transporter prediction server TransportTP (e value < 1e-05) (). Prediction of genes coding for nonribosomal peptide synthase (NRPS), polyketide synthase (PKS), hybrid NRPS-PKS, dimethylallyl tryptophan synthase (DMATS), and terpene cyclase (TC) was performed using the programs SMURF () and antiSMASH 2.0 () in combination (union). Identification of carbohydrate-acti […]

Citations

Looking to check out a full list of citations?

NRPS-PKS institution(s)
National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India
NRPS-PKS funding source(s)
Supported by grants to the National Institute of Immunology from the Department of Biotechnology, Government of India.

NRPS-PKS reviews

star_border star_border star_border star_border star_border
star star star star star

Be the first to review NRPS-PKS