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NRWRH specifications


Unique identifier OMICS_25005
Alternative name Network-based Random Walk with Restart on the Heterogeneous network
Software type Application/Script
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages MATLAB
Computer skills Advanced
Maintained Yes


No version available


  • person_outline Xing Chen
  • person_outline Guiying Yan
  • person_outline Ming-Xi Liu

Publication for Network-based Random Walk with Restart on the Heterogeneous network

NRWRH citations


Inferring new indications for approved drugs via random walk on drug disease heterogenous networks

BMC Bioinformatics
PMCID: 5259862
PMID: 28155639
DOI: 10.1186/s12859-016-1336-7

[…] predicting drug-target interactions and drug-disease associations in our empirical experiments. In fact, our method is inspired by the network-based random walk with restart on heterogenous network (NRWRH) [], which run only drug-centric random walk with restart on drug-target heterogenous network to predict new targets for a drug of interest. To test whether the two-pass NRWRH (TP-NRWRH) really […]


Improved genome scale multi target virtual screening via a novel collaborative filtering approach to cold start problem

Sci Rep
PMCID: 5153628
PMID: 27958331
DOI: 10.1038/srep38860

[…] To validate the algorithm, we compared it to a number of different methods for the same problem, namely KBMF2K, WNN, WNN-GIP, NetLapRLS, BLM-NII, CMF, NRLMF, PRW, REMAP, Chem08, Pharm10, DASPfind, NRWRH and HGBI in several different benchmarks, namely Yam, Yam, and ZINC. […]


Systems Medicine: The Application of Systems Biology Approaches for Modern Medical Research and Drug Development

PMCID: 4556074
PMID: 26357572
DOI: 10.1155/2015/698169

[…] ted for the purpose of drug/target interaction prediction studies, particularly for large and heterogeneous molecular interaction networks. Such methods include probabilistic matrix factorization and Network-based Random Walk with Restart on the Heterogeneous network (NRWRH) [, ]. Similarly, the importance of network pharmacology methods for the identification of novel drug/target networks for ind […]


A Semi Supervised Method for Drug Target Interaction Prediction with Consistency in Networks

PLoS One
PMCID: 3646965
PMID: 23667553
DOI: 10.1371/journal.pone.0062975

[…] curacy. Xia et al. proposed a semi-supervised learning method, NetLapRLS, to predict drug-protein interactions by using labeled and unlabeled information. Chen et al. developed an inference method, NRWRH, by random walk on heterogeneous network, including protein-protein similarity network, drug-drug similarity network, and known drug-target interaction networks. Based on complex network theory, […]


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NRWRH institution(s)
Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, China; Graduate University of Chinese Academy of Sciences, Beijing, China; National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences, Beijing, China
NRWRH funding source(s)
Supported by the National Natural Science of Foundation of China under Grant Nos. 10531070, 10721101, KJCX-YW-S7 and NCMIS.

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