Nuclear receptor databases | Protein sequence data analysis
Nuclear receptors (NRs) are a superfamily of transcription factors, distinct in their structural organization, whose activity can be switched on and off by small molecules and hormones. Despite major differences in the nature of the ligands to which NRs respond, they share several functional domains and a common structural organization.
An interactive, comprehensive and manually curated database of small molecule ligands targeting orphan nuclear receptors. ONRLDB consists of around 11 000 ligands, of which around 6500 are unique. All entries include information for the ligand, number of aromatic rings and rotatable bonds, XlogP, hydrogen donor and acceptor count, molecular weight (MW) and structure. The database can be searched using three methods: text search, advanced search or similarity search. Substructure search, cataloguing and clustering tools can be used to perform advanced analysis of the ligand based on chemical similarity fingerprints, hierarchical clustering, binning partition and multidimensional scaling.
A database for managing information about hormones and their receptors. Hmrbase is a highly curated database for which information has been collected from the literature and the public databases. Hmrbase can be searched on the basis of a variety of data types such as hormone and receptor description and their names, molecular weight, molecular formula, IUPAC name, smiles, physiochemical properties, post-translational modification, developmental stage, subcellular location, length of the protein sequence, organism name, etc.
A manually curated benchmarking database dedicated to the nuclear receptor (NR) ligands and structures pharmacological profiles. The NRLiSt BDB provides for the NRs having more than one agonist and one antagonist ligand and at least one experimental structure available, all available agonist and antagonist ligands identified in the literature. The 9905 compounds and 339 structures of the NRLiSt BDB are ready for structure-based and ligand-based virtual screening.
A database for the aggregation, discovery and analysis of hormone receptor binding sites in the mammalian genomes. HRTBLDb contains hormone receptor binding regions (binding loci) from in vivo ChIP-based high-throughput experiments as well as in silico, computationally predicted, binding motifs and cis-regulatory modules for the co-occurring transcription factor binding motifs, which are within a binding locus. It also contains individual binding sites whose regulatory action has been verified by in vitro experiments.
Provides information on members of the nuclear receptor superfamily. NRR includes individual resources as part of a network that integrates this information in the NRR home page. The database is related to glucocorticoid (GRR), thyroid hormone (THRR), mineralocorticoid (MRR), androgen (ARR) and vitamin D (VDRR) receptors as well as the steroid receptor associated proteins resource (SRAPR).
Provides data about mutations of the androgen receptor gene (AR). ARDB contains over 800 entries of mutations causing androgen insensitivity syndrome (AIS), representing over 500 different AR mutations from more than 850 patients with AIS. It reports about 45 specific mutations that are associated with variable phenotypes. The database conforms to the present Human Genome Variation Society (HGVS) standard reporting nomenclature.
Collects, combines, validates and disseminates large amounts of heterogeneous data on nuclear hormone receptors. The NucleaRDB provides researchers with a single point of access for nuclear receptor-related data, it contains both experimental and computationally derived data. The data and knowledge present in the NucleaRDB can be accessed using a number of different interactive and programmatic methods and query systems.