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HRTBLDb / Hormone Receptor Target Binding Loci Database
A database for the aggregation, discovery and analysis of hormone receptor binding sites in the mammalian genomes. HRTBLDb contains hormone receptor binding regions (binding loci) from in vivo ChIP-based high-throughput experiments as well as in silico, computationally predicted, binding motifs and cis-regulatory modules for the co-occurring transcription factor binding motifs, which are within a binding locus. It also contains individual binding sites whose regulatory action has been verified by in vitro experiments.
NRLiSt BDB / Nuclear Receptors Ligands and Structures Benchmarking DataBase
A manually curated benchmarking database dedicated to the nuclear receptor (NR) ligands and structures pharmacological profiles. The NRLiSt BDB provides for the NRs having more than one agonist and one antagonist ligand and at least one experimental structure available, all available agonist and antagonist ligands identified in the literature. The 9905 compounds and 339 structures of the NRLiSt BDB are ready for structure-based and ligand-based virtual screening.
A database for managing information about hormones and their receptors. Hmrbase is a highly curated database for which information has been collected from the literature and the public databases. Hmrbase can be searched on the basis of a variety of data types such as hormone and receptor description and their names, molecular weight, molecular formula, IUPAC name, smiles, physiochemical properties, post-translational modification, developmental stage, subcellular location, length of the protein sequence, organism name, etc.
ONRLDB / Orphan Nuclear Receptor Ligand Binding Database
An interactive, comprehensive and manually curated database of small molecule ligands targeting orphan nuclear receptors. ONRLDB consists of around 11 000 ligands, of which around 6500 are unique. All entries include information for the ligand, number of aromatic rings and rotatable bonds, XlogP, hydrogen donor and acceptor count, molecular weight (MW) and structure. The database can be searched using three methods: text search, advanced search or similarity search. Substructure search, cataloguing and clustering tools can be used to perform advanced analysis of the ligand based on chemical similarity fingerprints, hierarchical clustering, binning partition and multidimensional scaling.
Contains protein and DNA sequences, reviewed protein alignments and phylogenies, taxonomy and annotations for all nuclear receptors. The aim of NUREBASE is to present an integrated database, centralizing up-to-date information about nuclear receptors for the specialist and the non-specialist. It contains 523 nuclear receptor protein entries without redundancy, from 115 metazoan species. The sequences are grouped into 30 nested `families', corresponding to levels of nomenclature, each with an alignment and a phylogeny. NUREBASE also contains 771 nuclear receptor cDNA entries.
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