Unlock your biological data
Nuclear receptors (NRs) are a superfamily of transcription factors, distinct in their structural organization, whose activity can be switched on and off by small molecules and hormones. Despite major differences in the nature of the ligands to which NRs respond, they share several functional domains and a common structural organization.
(Nanduri et al., 2015) ONRLDB--manually curated database of experimentally validated ligands for orphan nuclear receptors: insights into new drug discovery. Database (Oxford).