Nucleosomes are the major structural elements of chromatin. Each nucleosome is formed by a 147 bp DNA fragment wrapped around an octamer composed of pairs of histone molecules of four types. In addition to DNA compacting, the most important function of nucleosomes is their interaction with the molecular components of the nucleus machineries involved in DNA replication, repair and recombination. The key role in gene transcription is also assigned to nucleosomes.
Consists of an open resource and platform for nucleosome positioning data from MNase-Seq across species. NucMap is a database that contains more than 790 experimental data from about 470 samples across 15 species. It also provides services for integrating, analyzing, and visualizing nucleosome positioning data across species. Users can search profile of nucleosome positioning at the promoter region of each gene across all samples and make enrichment analysis on nucleosome positioning data in all genomic regions.
Provides a comprehensive parts list of functional elements in the human genome. ENCODE is an online resource that includes elements that act at the protein and RNA levels, and regulatory elements that control cells and circumstances in which a gene is active. This corpus of data provides an astounding resource for annotation, curation and functional characterization in the human and mouse genomes in a large variety of sample types.