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ICM / Interactive Chromatin Modeling
Allows users to assess nucleosome stability and fold sequences of DNA into putative chromatin templates. ICM generates a nucleosome energy level diagram, coarse-grained representations of free DNA and chromatin and plots of the helical parameters (Tilt, Roll, Twist, Shift, Slide and Rise) as a function of position. It uses an elastic model to automatically place nucleosomes. The tool can be used to y assemble models of chromatin that can be employed to rationalize biophysical data, especially spatial relations.
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