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Nucleosome positioning software tools | MNase sequencing data analysis

Nucleosomes consisting of approximately 146 base pairs (bp) of DNA wrapped around a histone octamer are the fundamental structural units of chromatin in metazoans (Kornberg and Lorch, 1999;Kornberg and Lorch, 2002). The translational positioning of nucleosomes along DNA is implicated in profoundly influencing gene expression (Henikoff et al., 2004Kingston and Narlikar, 1999Kouzarides, 2007 Li et al., 2007). Thus, defining the nucleosome positioning and occupancy is critical to understand the mechanisms of regulation of transcription by chromatin. Source text : Cui and Zhao, 2012

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