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NURSA specifications


Unique identifier OMICS_02947
Alternative name Nuclear Receptor Signaling Atlas
Restrictions to use None
Maintained Yes


  • Primates
    • Homo sapiens
  • Rodents
    • Mus musculus
    • Rattus norvegicus


  • person_outline Margolis R.N.

Publication for Nuclear Receptor Signaling Atlas

NURSA citations


A proteomics landscape of circadian clock in mouse liver

Nat Commun
PMCID: 5908788
PMID: 29674717
DOI: 10.1038/s41467-018-03898-2

[…] ythm (Supplementary Fig. ). While the diurnal rhythms of the 7 NRs passed the JTK_CYCLE test, Mlr, Vdr, and Esr1 displayed single-pulse. Compared with the previous work on mRNA level conducted by the Nuclear Receptor Signaling Atlas (NURSA), we found that Pparσ, Trα, Rev-erbα, and Tr2 were diurnal rhythmic on both transcription level and DBA level, while Rorα, Lxrβ, Rxrβ were only diurnal rhythmic […]


Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

Nucleic Acids Res
PMCID: 4987924
PMID: 27141961
DOI: 10.1093/nar/gkw377

[…] ries from HumanCyc (), a metabolic pathway resource stored in BioPAX format (); gene and small-molecule perturbations from the LINCS L1000 data set; NCI-Nature pathways (); protein complexes from the NURSA project (); pathways from the PANTHER resource (); targets of phosphatases from DEPOD (); human phenotypes from the Human Phenotype Ontology (HPO) (); genes associated with grants using NIH RePO […]


Nuclear Receptor Signaling Atlas: Opening Access to the Biology of Nuclear Receptor Signaling Pathways

PLoS One
PMCID: 4556694
PMID: 26325041
DOI: 10.1371/journal.pone.0135615

[…] ercase text, with the known modification type at that numbered residue also given with a RefSeq identifier for cross-referencing purposes. Many miRNAs have been predicted to target various genes, but NURSA shows only miRNAs that have been experimentally validated to target a given gene product within its Targeting miRNAs subsection.Beneath the ortholog-specific sections, additional data for Datase […]


Genomics of ADME gene expression: mapping expression quantitative trait loci relevant for absorption, distribution, metabolism and excretion of drugs in human liver

Pharmacogenomics J
PMCID: 3564008
PMID: 22006096
DOI: 10.1038/tpj.2011.44

[…] e context of ADME processes. We compiled an ADME gene set comprising 682 genes () from various resources including the PharmaADME Working Group list of ADME genes (, the NURSA (Nuclear Receptor Signaling Atlas) Consortium and the PharmGKB knowledge base ( By requesting either SNP or trait gene or both to be an ADME gene, we identified a total of 95 […]


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NURSA institution(s)
Division of Diabetes, Endocrinology, and Metabolic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, MD, USA
NURSA funding source(s)
Supported by NIDDK, NHLBI, and NIEHS.

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