Provides a model for antibody dependent cellular cytotoxicity (ADCC). ODE model can extract natural killer (NK) cells kill tumour cells from in vitro cytotoxicity data by applying perturbation methods. It is able to relate the rate at which NK cells kill in response to binding antibody with the percentage of cancer cells killed at the end of a cytotoxicity assay. This tool can predict how different initial antibody levels yield different information about the functional form of the kill rate function.
Department of Computer Science, University of Oxford, Oxford, UK; School of Mathematics and Statistics, University of Melbourne, VIC, Australia; Quantitative Biology, Astrazeneca Ltd., Cambridge, UK; Computational Biology, Astrazeneca Ltd., Alderley Edge, UK; Beyond Consulting Ltd., BioHub, Alderley Park, Cheshire, UK; Medimmune Ltd., Cambridge, UK; Mathematical Institute, University of Oxford, Oxford, UK
ODE model funding source(s)
Supported by the ESPRC, MRC, Astrazeneca and Medimmune.