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Odefy specifications


Unique identifier OMICS_20162
Name Odefy
Software type Toolkit/Suite
Interface Command line interface, Graphical user interface
Restrictions to use Academic or non-commercial use
Operating system Unix/Linux, Mac OS, Windows
Programming languages MATLAB
Computer skills Advanced
Version 1.19
Stability Stable
Octave (for non-GUI mode)
Maintained Yes




No version available


  • person_outline Fabian Theis <>

Publications for Odefy

Odefy citations


Exploring Wound Healing Genomic Machinery with a Network Based Approach

PMCID: 5490412
PMID: 28635674
DOI: 10.3390/ph10020055

[…] these nodes, tnf, rela and nfkb1, are all set to 1 and are highlighted in red in . on the other hand, initial values of the other network nodes are randomly assigned to 0 or 1 (). we next applied odefy, which performs the conversion of bns into continuous odes, with continuous time descriptions, and gives as an output the node behaviors after a certain stimulus (here rigenera® action). […]


Simulation of the dynamics of primary immunodeficiencies in CD4+ T cells

PMCID: 5407609
PMID: 28448599
DOI: 10.1371/journal.pone.0176500

[…] quation x˙i =1τi(b¯i (x¯i1, x¯i2,…, x¯ini)− x¯i), where, b¯i is a continuous homologue of the discrete function bi, parameter τi represents the life-time of the protein, and x¯i describes its decay., odefy [], a toolbox compatible with matlab, transforms bi to the ode system and computes the solution of the system using the boolecubes [] as follows, b¯i(x¯1, x¯2,…, x¯n)= ∑x1=01∑x1=01…∑xn=01[b(x1,  […]


A Network Based Data Integration Approach to Support Drug Repurposing and Multi Target Therapies in Triple Negative Breast Cancer

PMCID: 5025072
PMID: 27632168
DOI: 10.1371/journal.pone.0162407

[…] more understandable information about general pathway dynamics under different conditions. to support these studies, publicly available software tools such as booleannet [], pathologic-s [] and odefy [] have been developed; they offer a scalable boolean framework for modeling cellular signaling., following these considerations, in this work we present a novel bioinformatics pipeline […]


Multiple Model Informed Open Loop Control of Uncertain Intracellular Signaling Dynamics

PMCID: 3983080
PMID: 24722333
DOI: 10.1371/journal.pcbi.1003546

[…] logic to describe the main steps involved in the activation of cd4+ helper t cells. cellnetanalyzer, a matlab software package for structural and functional analysis of signaling networks, and the odefy toolbox were used to convert the logical model to a continuous homologue (herein referred to as model k) with 40 states and 147 reaction parameters. values for these reaction parameters […]


A Parallel Attractor Finding Algorithm Based on Boolean Satisfiability for Genetic Regulatory Networks

PMCID: 3981794
PMID: 24718686
DOI: 10.1371/journal.pone.0094258

[…] of finding attractors have been extensively studied in the past decade , –. a few of these algorithms are available as released tools, such as genetic network analyser , squad , cellnetanalyzer , odefy , jemena , etc. all these existing algorithms can be categorized into four groups. the simulation-based approach is proposed to find attractors by choosing several initial states heuristically […]


Modeling approaches for qualitative and semi quantitative analysis of cellular signaling networks

PMCID: 3698152
PMID: 23803171
DOI: 10.1186/1478-811X-11-43

[…] a known artifact of the synchronous approach []., several software tools exist that enable the dynamic modeling of logical networks. examples are ginsim [], squad [], booleannet [], chemchains [], odefy [], and boolnet []., in figure a we see the dynamic response of the egf/nrg1 model using synchronous updating and setting the initial values for egf, erbb1, erbb2, and erbb3 to 1, […]

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Odefy institution(s)
Institute for Bioinformatics and Systems Biology, Helmholtz Zentrum München, Munich-Neuherberg, Germany; Department of Mathematics, Technische Universität München, Garching, Germany
Odefy funding source(s)
Partially supported by the Initiative and Networking Fund of the Helmholtz Association within the Helmholtz Alliance on Systems Biology (project CoReNe).

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