An integrated database and software suite for site specific targeting of transcription factors of cancer genes. Onco-Regulon combines into a single platform (i) a database of functional regulatory motifs in 937 cancer causing genes and (ii) developed a software USP (Unique Sequence Predictor) to predict unique target motifs for drug binding in a gene specific manner. We believe that Onco-Regulon will help researchers to design drugs which will bind to an exclusive site in the genome with no off-target effects, theoretically.
Supercomputing Facility for Bioinformatics & Computational Biology, Indian Institute of Technology-Delhi, New Delhi, India; Kusuma School of Biological Sciences, Indian Institute of Technology-Delhi, Delhi, India; Labaratory of Molecular Biology, South Asian University, New Delhi, India; Department of Chemistry, Indian Institute of Technology-Delhi, Delhi
Onco-Regulon funding source(s)
Centre of excellence grant from Department of Biotechnology, Government of India, Department of Biotechnology, Government of India, Junior Research Fellowship Scheme of University Grants Commission, Innovative Young Biotechnologist Award (IYBA) grant from Department of Biotechnology, Government of India