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Unique identifier OMICS_33717
Name Oncofinder


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Publication for Oncofinder

Oncofinder citations


Drug Repositioning in Glioblastoma: A Pathway Perspective

Front Pharmacol
PMCID: 5864870
PMID: 29615902
DOI: 10.3389/fphar.2018.00218

[…] of targeted cancer drugs for individual patients, Armetov et al. used gene expression signatures of individual tumor samples and predicted a drug score based on signaling pathway activation analysis (OncoFinder algorithm). They tested the approach for five drugs in seven cancer types and reported significant correlation of responders to drug treatment and the percent of tumors showing high drug sc […]


Profiling of Human Molecular Pathways Affected by Retrotransposons at the Level of Regulation by Transcription Factor Proteins

Front Immunol
PMCID: 5797644
PMID: 29441061
DOI: 10.3389/fimmu.2018.00030

[…] for the individual genes, for the first time we could identify the molecular processes most strongly impacted by the RE regulatory features. To this end, we applied and modified bioinformatic method Oncofinder that has been used before only for the analysis of gene or microRNA expression profiles () and could effectively reduce experimental noise caused by different experimental platforms and bat […]


Adverse effects of paternal chemotherapy exposure on the progeny brain: intergenerational chemobrain

PMCID: 5839372
PMID: 29515791
DOI: 10.18632/oncotarget.24311

[…] de excellent tools to analyse biological repercussions of transgenerational effects, they do not allow quantitative pathway activation analysis. This can be achieved using novel platforms such as the OncoFinder or iPANDA. In the future, we will apply OncoFinder and iPANDA to analyse the pathway activation strength [, ]. This approach can also be used to compare transgenerational effects in differe […]


Acquired resistance to tyrosine kinase inhibitors may be linked with the decreased sensitivity to X ray irradiation

PMCID: 5797037
PMID: 29435166
DOI: 10.18632/oncotarget.23700

[…] The Oncofinder knowledge base was used to determine structures of intracellular molecular pathways linked with DNA repair, as described previously []. We applied the original OncoFinder algorithm [] for f […]


The anti tumorigenic activity of A2M—A lesson from the naked mole rat

PLoS One
PMCID: 5744951
PMID: 29281661
DOI: 10.1371/journal.pone.0189514

[…] Differential pathway analysis was performed with OncoFinder []. In order to comply with the previously established protocol [], raw reads were filtered by quality > 30 score through FASTX toolkit and then trimmed at 5‘ and 3‘ in order to remove inde […]


Towards natural mimetics of metformin and rapamycin

PMCID: 5723685
PMID: 29165314
DOI: 10.18632/aging.101319

[…] s-platform analysis, and high dimensionality of microarray datasets, much information remains unparsed.To overcome and even exploit these challenges, we have developed bioinformatic methods including Oncofinder [,], Geroscope [], and in silico Pathway Activation Network Decomposition Analysis (iPANDA) [], which extract robust, biologically relevant pathway activation signatures from the data by co […]


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Oncofinder institution(s)
Pathway Pharmaceuticals, Limited, Wan Chai, Hong Kong, Hong Kong; D. Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia; Biological and Medical Physics, Moscow Institute of Physics and Technology, Dolgoprudny, Russia; Burnasyan Federal Medical Biophysical Center, Moscow, Russia

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