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DGIdb 3.0: a redesign and expansion of the drug–gene interaction database
[…] ert-curated databases of clinically actionable variants similar to the CIViC and Clearity Foundation sources, already included in the DGIdb () (). These include the Precision Oncology Knowledge Base (OncoKB), cancer genome interpreter (CGI) and The Jackson Laboratory Clinical Knowledgebase (CKB) () (,). From these three new sources, 2822 new interaction claims were added. These sources were added […]
Resources for Interpreting Variants in Precision Genomic Oncology Applications
[…] provides scored clinical annotation, prescription annotation (drug dosing, prescribing information), as well as pharmacokinetics/pharmacodynamics (PK/PD) annotation, with primary literature reference.OncoKb contains information on the clinical implication of specific genetic alterations in cancer. Each variant is annotation from multiple sources and scored using Levels of Evidence ranging from Lev […]
CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer
[…] ized Cancer Therapy Knowledgebase, https://pct.mdanderson.org/; Precision Medicine Knowledgebase, https://pmkb.weill.cornell.edu/; Cancer Genome Interpreter, https://www.cancergenomeinterpreter.org/; OncoKB, http://oncokb.org/; GitHub, https://github.com/; GA4GH Variant Interpretation for Cancer Consortium (VICC), http://ga4gh.org/#/vicc; MIT license, https://open-source.org/licenses/MIT; CC0 lice […]
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