Open TG-GATEs

[…] Liver-related treatments from the Open TG-GATEs database were employed to assess the predictive ability of the PTGS-associated gene sets against external data. The complete data was downloaded from the publisher’s web site (http://dba […]

[…] of functions, while the tools mentioned above have much more specific purposes.Although ToxDBScan and NFFinder utilise a wider range of data than Toxygates, we believe that our policy to utilise only Open TG-GATEs as a reference database is favourable to obtain biologically informative results at this point in time. Although we successfully obtained informative results in our case study by importi […]

[…] e present our efforts in identifying sets of genes (modules) that are characteristic of and specific to a wide variety of chemical exposure conditions causing liver and/or kidney injuries.We used the Open Toxicogenomics Project‐Genomics Assisted Toxicity Evaluation System (TG‐GATEs) to generate sets of genes related to graded histopathology assessments of liver and kidney damage as manifestations […]

[…] The Japanese Toxicogenomics Project has generated the Open TG-GATEs data repository of gene expression profiles in PHH upon exposure to 157 compounds, of which many are DILI-related, at 1–3 different concentrations and 1–3 time points (2, 8 and 24 h), in […]

[…] a from toxicogenomics project repositories and public databases. Apart from data from European projects, diXa also includes the public data from the National Project of Toxicogenomics in Japan, named Open TG-GATES (Toxicogenomics Project-Genomics Assisted Evaluation System, see below for more details).The diXa data warehouse connects multi-omics studies, deposited in EBI resources [ArrayExpress fo […]