Open TG-GATEs statistics

Tool stats & trends

Looking to identify usage trends or leading experts?

Open TG-GATEs specifications


Unique identifier OMICS_06026
Name Open TG-GATEs
Alternative name Open Toxicogenomics Project-Genomics Assisted Toxicity Evaluation System
Restrictions to use None
Maintained Yes

Publication for Open Toxicogenomics Project-Genomics Assisted Toxicity Evaluation System

Open TG-GATEs citations


A transcriptomics data driven gene space accurately predicts liver cytopathology and drug induced liver injury

Nat Commun
PMCID: 5500850
PMID: 28671182
DOI: 10.1038/ncomms15932

[…] Liver-related treatments from the Open TG-GATEs database were employed to assess the predictive ability of the PTGS-associated gene sets against external data. The complete data was downloaded from the publisher’s web site (http://dba […]


Interactive Toxicogenomics: Gene set discovery, clustering and analysis in Toxygates

Sci Rep
PMCID: 5431224
PMID: 28469246
DOI: 10.1038/s41598-017-01500-1

[…] of functions, while the tools mentioned above have much more specific purposes.Although ToxDBScan and NFFinder utilise a wider range of data than Toxygates, we believe that our policy to utilise only Open TG-GATEs as a reference database is favourable to obtain biologically informative results at this point in time. Although we successfully obtained informative results in our case study by importi […]


Systems toxicology of chemically induced liver and kidney injuries: histopathology‐associated gene co‐expression modules

J Appl Toxicol
PMCID: 5064727
PMID: 26725466
DOI: 10.1002/jat.3278

[…] e present our efforts in identifying sets of genes (modules) that are characteristic of and specific to a wide variety of chemical exposure conditions causing liver and/or kidney injuries.We used the Open Toxicogenomics Project‐Genomics Assisted Toxicity Evaluation System (TG‐GATEs) to generate sets of genes related to graded histopathology assessments of liver and kidney damage as manifestations […]


Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF κB activation and sensitizes toward TNFα induced cytotoxicity

PMCID: 4830895
PMID: 26026609
DOI: 10.1007/s00204-015-1536-3

[…] The Japanese Toxicogenomics Project has generated the Open TG-GATEs data repository of gene expression profiles in PHH upon exposure to 157 compounds, of which many are DILI-related, at 1–3 different concentrations and 1–3 time points (2, 8 and 24 h), in […]


Workshop report: Identifying opportunities for global integration of toxicogenomics databases, 26–27 June 2013, Research Triangle Park, NC, USA

PMCID: 4247478
PMID: 25326818
DOI: 10.1007/s00204-014-1387-3

[…] a from toxicogenomics project repositories and public databases. Apart from data from European projects, diXa also includes the public data from the National Project of Toxicogenomics in Japan, named Open TG-GATES (Toxicogenomics Project-Genomics Assisted Evaluation System, see below for more details).The diXa data warehouse connects multi-omics studies, deposited in EBI resources [ArrayExpress fo […]


Looking to check out a full list of citations?

Open TG-GATEs institution(s)
Toxicogenomics Informatics Project, National Institute of Biomedical Innovation, Osaka, Japan

Open TG-GATEs reviews

star_border star_border star_border star_border star_border
star star star star star

Be the first to review Open TG-GATEs