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Open TG-GATEs specifications

Information


Unique identifier OMICS_06026
Name Open TG-GATEs
Alternative name Open Toxicogenomics Project-Genomics Assisted Toxicity Evaluation System
Restrictions to use None
Maintained Yes

Publication for Open Toxicogenomics Project-Genomics Assisted Toxicity Evaluation System

Open TG-GATEs citations

 (5)
library_books

A transcriptomics data driven gene space accurately predicts liver cytopathology and drug induced liver injury

2017
Nat Commun
PMCID: 5500850
PMID: 28671182
DOI: 10.1038/ncomms15932

[…] Liver-related treatments from the Open TG-GATEs database were employed to assess the predictive ability of the PTGS-associated gene sets against external data. The complete data was downloaded from the publisher’s web site (http://dba […]

library_books

Interactive Toxicogenomics: Gene set discovery, clustering and analysis in Toxygates

2017
Sci Rep
PMCID: 5431224
PMID: 28469246
DOI: 10.1038/s41598-017-01500-1

[…] of functions, while the tools mentioned above have much more specific purposes.Although ToxDBScan and NFFinder utilise a wider range of data than Toxygates, we believe that our policy to utilise only Open TG-GATEs as a reference database is favourable to obtain biologically informative results at this point in time. Although we successfully obtained informative results in our case study by importi […]

library_books

Systems toxicology of chemically induced liver and kidney injuries: histopathology‐associated gene co‐expression modules

2016
J Appl Toxicol
PMCID: 5064727
PMID: 26725466
DOI: 10.1002/jat.3278

[…] e present our efforts in identifying sets of genes (modules) that are characteristic of and specific to a wide variety of chemical exposure conditions causing liver and/or kidney injuries.We used the Open Toxicogenomics Project‐Genomics Assisted Toxicity Evaluation System (TG‐GATEs) to generate sets of genes related to graded histopathology assessments of liver and kidney damage as manifestations […]

library_books

Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF κB activation and sensitizes toward TNFα induced cytotoxicity

2015
PMCID: 4830895
PMID: 26026609
DOI: 10.1007/s00204-015-1536-3

[…] The Japanese Toxicogenomics Project has generated the Open TG-GATEs data repository of gene expression profiles in PHH upon exposure to 157 compounds, of which many are DILI-related, at 1–3 different concentrations and 1–3 time points (2, 8 and 24 h), in […]

library_books

Workshop report: Identifying opportunities for global integration of toxicogenomics databases, 26–27 June 2013, Research Triangle Park, NC, USA

2014
PMCID: 4247478
PMID: 25326818
DOI: 10.1007/s00204-014-1387-3

[…] a from toxicogenomics project repositories and public databases. Apart from data from European projects, diXa also includes the public data from the National Project of Toxicogenomics in Japan, named Open TG-GATES (Toxicogenomics Project-Genomics Assisted Evaluation System, see below for more details).The diXa data warehouse connects multi-omics studies, deposited in EBI resources [ArrayExpress fo […]

Citations

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Open TG-GATEs institution(s)
Toxicogenomics Informatics Project, National Institute of Biomedical Innovation, Osaka, Japan

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