OrthoClust statistics

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Associated diseases

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OrthoClust specifications


Unique identifier OMICS_05475
Name OrthoClust
Software type Application/Script
Interface Command line interface
Restrictions to use None
Input data A network file and a coupling information file.
Input format TSV
Output data A file with three columns: the species id, the gene id given by the input files and a module id.
Output format TSV
Operating system Unix/Linux
Programming languages MATLAB, R
Computer skills Advanced
Stability Stable
Maintained Yes


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  • person_outline Mark Gerstein <>

Publication for OrthoClust

OrthoClust in publications

PMCID: 5034284
PMID: 27659694
DOI: 10.1038/srep34019

[…] in order to investigate the role of ips in aml subsets we split tcga amls into two classes: m5 and non-m5. we then created correlation networks for each class and performed co-clustering using orthoclust for both networks (). we then retrieved the genes correlated to ip genes within each cluster and performed go term enrichment on each gene set. enriched go terms were grouped into general […]

PMCID: 4426649
PMID: 25887590
DOI: 10.1186/s12864-015-1496-2

[…] i.e. if a certain go term exists in 50% or more of the genes in a clique, then it is assigned to the remaining genes in the same clique. a more recent study [], proposes a computational framework (orthoclust) that integrates single species co-association networks into data clusters across multiple species via orthology relationships. their framework is applied on rna-seq expression profiles […]

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OrthoClust institution(s)
Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA; Department of Computer Science, Yale University, New Haven, CT, USA; Department of Genetics, Dartmouth School of Medicine, Hanover, NH, USA
OrthoClust funding source(s)
Supported by the Yale University Faculty of Arts and Sciences High Performance Computing Center.

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