Unravels the host–parasite interactome across 12 human parasites. OrthoHPI is based on orthology and its strengths. This tool (1) incorporates high–confidence intra–species interactions, (2) uses fined grained orthology assignments instead of simple sequence similarity and (3) includes parasite–specific biological context. The platform can be useful in parasites genomics, considering that a large number of parasite´s proteins are annotated as hypothetical proteins, it provides a useful resource for annotation of those proteins.
Centro de Pesquisas René Rachou (CpqRR), Fundação Oswaldo Cruz (FIOCRUZ), Belo Horizonte, Brazil; Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil; Instituto Tecnologico Vale, Belém, PA, Brazil; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
OrthoHPI funding source(s)
Supported by grants from the National Institutes of Health-NIH/Fogarty International Center (TW007012), a CNPq fellow (307479/2016-1), and CAPES (REDE 21/2015 CAPES/MINCYT), EMBO short-term fellowship (400-2015) and by the Novo Nordisk Foundation (Grant number NNF14CC0001).