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Contains ortholog groups for most completely sequenced and annotated eukaryotes for a number of completely sequenced and annotated prokaryotes. OrthoMCL-DB provides a wealth of functionality, including domain architecture for each group, phyletic patterns for each group and advanced querying, including phylogenetic pattern searches. The database gives also access to OrthoMCL, which groups proteins into “ortholog groups” (i.e. set of proteins across one or more species that represent putative orthologs and in-paralogs).

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OrthoMCL-DB classification

OrthoMCL-DB specifications

Restrictions to use:
Community driven:
User data submission:
Not allowed
Database management system:
Data access:
File download, Browse


  • OrthoMCL

OrthoMCL-DB support


  • David Roos <>
  • Steve Fischer <>
  • OrthoMCL-DB Team <>


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Center for Bioinformatics, University of Pennsylvania, Philadelphia PA, USA; Department of Biology, University of Pennsylvania, Philadelphia PA, USA; Department of Genetics, University of Pennsylvania, Philadelphia PA, USA; Bayer Business and Technology Services, Bayer Healthcare Pharmaceuticals, NJ, USA

Funding source(s)

Supported by the National Institute of Allergy and Infectious Diseases at the National Institutes of
Health [Award NO1-AI900038C Contract No. HHSN272200900038C].

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