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OS-Seq specifications


Unique identifier OMICS_04176
Name OS-Seq
Alternative name Oligonucleotide-Selective Sequencing
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages MATLAB
Computer skills Advanced
Maintained No


No version available


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Publication for Oligonucleotide-Selective Sequencing

OS-Seq citations


Genetics and genotype–phenotype correlations in Finnish patients with dilated cardiomyopathy

Eur Heart J
PMCID: 4561350
PMID: 26084686
DOI: 10.1093/eurheartj/ehv253

[…] ve a smaller spectrum of rare variation. To investigate the genetic landscape of DCM in the Finnish population, to evaluate associations between genotype and phenotype, and to evaluate the utility of OS-Seq technology as a novel comprehensive diagnostic tool, we developed and utilized a high-quality 101-gene OS-Seq-based targeted resequencing panel. In this study, we show excellent sequencing perf […]


Accurate genetic diagnosis of Finnish pulmonary arterial hypertension patients using oligonucleotide selective sequencing

PMCID: 4521970
PMID: 26247051
DOI: 10.1002/mgg3.147

[…] ent, reliable, and high-depth sequencing of clinically relevant genomic regions with complete coverage.To demonstrate the utility of NGS in the diagnostics of inherited diseases, we have developed an OS-Seq sequencing panel to accurately detect mutations in seven genes that have been implicated in the pathogenesis of PAH. We collected over 900 mutations from literature and existing databases to su […]


A tale of three next generation sequencing platforms: comparison of Ion Torrent, Pacific Biosciences and Illumina MiSeq sequencers

BMC Genomics
PMCID: 3431227
PMID: 22827831
DOI: 10.1186/1471-2164-13-341

[…] technology, many of those applications should translate well and be equally practicable. There are a few obvious exceptions; techniques involving manipulations on the flow cell such as FRT-seq [] and OS-Seq [] will be impossible using semiconductor sequencing. Also, the Ion Torrent platform currently employs fragment lengths of 100 or 200 bases; without a mate-pair type library protocol, these ins […]


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OS-Seq institution(s)
Stanford Genome Technology Center, Stanford University, Palo Alto, CA, USA; Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA; Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA
OS-Seq funding source(s)
Supported by the National Institutes of Health [NCI Innovative Molecular Analysis Technologies grant 1R33CA174575, P01HG000205, American Cancer Society [Research Scholar Grant RSG-13-297-01-TBG], Wang Foundation, Doris Duke Clinical Foundation, Clayville Foundation and the Howard Hughes Medical Institute.

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