Cysteine oxidative modification databases | Post-translational modification data analysis
Redox regulation and signaling, which are involved in various cellular processes, have become one of the research focuses in the past decade. Cysteine thiol groups are particularly susceptible to post-translational modification, and their reversible oxidation is of critical role in redox regulation and signaling. With the tremendous improvement of techniques, hundreds of redox proteins along with their redox-sensitive cysteines have been reported, and the number is still fast growing.
Deals with information related to post translational modifications (PTMs) in plants. Plant PTM Viewer offers a repository of information curated from more than 120 scientific publications proposing a framework for protein visualization as well as tools for further investigation. It also provides a search engine enabling to find ambiguous or specific amino acid motifs that are modified by one or more PTMs.
Provides information about protein oxidative modification verified by experimental studies. For each modified cysteine, the exact position, modification type and flanking sequence are provided. Additional information, including gene name, organism, sequence, literature references and links to UniProt and PDB, is also supplied. The database supports several functions including data search, blast and browsing. RedoxDB not only includes data from case-by-case studies but also integrates high-throughput data from proteomics studies. RedoxDB is useful for both experimental studies and computational analyses of protein oxidative modification.