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PAIL specifications


Unique identifier OMICS_10769
Alternative name Prediction of Acetylation on Internal Lysines
Interface Web user interface
Restrictions to use None
Input data Protein sequence(s)
Input format FASTA, Raw
Computer skills Basic
Stability Stable
Maintained Yes

Publication for Prediction of Acetylation on Internal Lysines

PAIL citations


Evidence for a radiation responsive ‘p53 gateway’ contributing significantly to the radioresistance of lepidopteran insect cells

Sci Rep
PMCID: 5758781
PMID: 29311662
DOI: 10.1038/s41598-017-18521-5

[…] studied using Hex 8.0 tool using Sfp53 model. The phosphorylation status of Sfp53 was predicted by NetPhos 2.0 and GPS 2.1. Acetylation status of the Carboxy terminus domain (CTD) was predicted using PAIL: Prediction of Acetylation on Internal Lysines and LAceP: Lysine Acetylation Site Prediction. […]


Protein post translational modifications: In silico prediction tools and molecular modeling

Comput Struct Biotechnol J
PMCID: 5397102
PMID: 28458782
DOI: 10.1016/j.csbj.2017.03.004

[…] ammalian acetylated substrates. However, NetAcet suffered from the limited size of the training dataset available at that time of development. Several web-servers aimed to predict acetylated lysine. PAIL was the first in silico tool for Nε-lysine acetylation sites' prediction. The Bayesian discriminant algorithm was employed on a training set of 246 experimentally verified acetylated sites. Des […]


Mutation Structure Function Relationship Based Integrated Strategy Reveals the Potential Impact of Deleterious Missense Mutations in Autophagy Related Proteins on Hepatocellular Carcinoma (HCC): A Comprehensive Informatics Approach

Int J Mol Sci
PMCID: 5297772
PMID: 28085066
DOI: 10.3390/ijms18010139

[…] e tumor suppressor genes and enhance cancer progression []. For the prediction of acetylation sites in LC3A, LC3B, BECN1 and SCD1, web servers ASEB ( [] and PAIL ( [] were used. […]


Data on evolution of intrinsically disordered regions of the human kinome and contribution of FAK1 IDRs to cytoskeletal remodeling

PMCID: 5157709
PMID: 28004021
DOI: 10.1016/j.dib.2016.11.099

[…] We predicted phosphorylation sites using disPhos and netphos , acetylation sites using PAIL , and ubiquitylation sites using UbPred . These PTM predictors, in addition to predicting novel PTM sites, also predict and report the PTM sites that are already experimentally validated. We have […]


Acetylation of glucokinase regulatory protein decreases glucose metabolism by suppressing glucokinase activity

Sci Rep
PMCID: 4664969
PMID: 26620281
DOI: 10.1038/srep17395

[…] onstrated that C646 treatment decreased GKRP acetylation (), indicating that p300 acetylates GKRP.To determine the possible site(s) of GKRP acetylation, Prediction of Acetylation on Internal Lysines (PAIL) software ( revealed three potential N-terminal acetylation sites, Lys5 (K5), Lys170 (K170), and Lys261 (K261), all conserved among human, mouse, and rat GKRP protein […]


Evolution of disorder in Mediator complex and its functional relevance

Nucleic Acids Res
PMCID: 4770211
PMID: 26590257
DOI: 10.1093/nar/gkv1135
call_split See protocol

[…] thaliana, O. saitva subsp. japonica, C. elegans, D. melanogaster, D. rerio, G. gallus and H. sapiens. PTMs were predicted with freely available web tools NetPhos 2.0 (), NetNGlyc 1.0 (), PMeS () and PAIL () with default parameters. A stretch of 30 residues in Mediator complex subunits was considered as PTM hotspot if the fraction of predicted PTM sites in this stretch was between 0.1 and 0.3. […]


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PAIL institution(s)
Department of Pathology, School of Medicine, Yale University, New Haven, CT, USA; Laboratory of Cellular Dynamics, Hefei National Laboratory for Physical Sciences, and the University of Science and Technology of China, Hefei, China; College of Life Science and Bioengineering, Beijing University of Technology, Beijing, China; Department of Physiology and Cancer Research Program, Morehouse School of Medicine, Atlanta, GA, USA

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