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PANTHER specifications


Unique identifier OMICS_00135
Alternative name Protein ANalysis THrough Evolutionary Relationships
Interface Web user interface
Restrictions to use None
Computer skills Basic
Version 10.0
Stability Stable
Maintained Yes


  • Primates
    • Homo sapiens


  • person_outline Paul D. Thomas

Additional information

A R package containing data is available at

Publications for Protein ANalysis THrough Evolutionary Relationships

PANTHER citations


Conditional genetic screen in Physcomitrella patens reveals a novel microtubule depolymerizing end tracking protein

PLoS Genet
PMCID: 5944918
PMID: 29746462
DOI: 10.1371/journal.pgen.1007221

[…] in the Phytozome web portal ( or the ENTREZ web portal ( In most cases only a single gene locus was identified. This is consistent with results from the Panther Classification System for gene families ( All sequences analyzed and the corresponding accession numbers are listed in . Multiple alignment and gene construction were done u […]


Isozyme specific comprehensive characterization of transglutaminase crosslinked substrates in kidney fibrosis

Sci Rep
PMCID: 5943318
PMID: 29743665
DOI: 10.1038/s41598-018-25674-4

[…] The identified proteins were annotated with Gene Ontology (GO) information from the Uniprot database using Gene Ontology Consortium ( and Protein Analysis Through Evolutionary Relationships ( The results, describing no more than 15 of the identified genes, are shown in Figs  and S. The identified substrates for TG […]


Functional and structural characterization of osteocytic MLO Y4 cell proteins encoded by genes differentially expressed in response to mechanical signals in vitro

Sci Rep
PMCID: 5928037
PMID: 29712973
DOI: 10.1038/s41598-018-25113-4

[…] t and the mouse proteome using a two-sample Kolmogorov-Smirnov test (K-S test) and assumed that a given difference is significant at p-values < 0.05.We performed functional analysis using GO with the PANTHER system. PANTHER performs enrichment analysis of GO terms associated with our proteins encoded by differentially expressed genes against the expected frequency of these terms in the mouse prote […]


The senescence associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1

Nat Commun
PMCID: 5928226
PMID: 29712904
DOI: 10.1038/s41467-018-04010-4

[…] Gene transcripts expressed in PSC27 stroma cells were analyzed with PANTHER ( and Ingenuity Pathway Analysis (IPA) ( Using PANTHER, protein classification was performed according to three ontological term […]


Comparative systems analysis of the secretome of the opportunistic pathogen Aspergillus fumigatus and other Aspergillus species

Sci Rep
PMCID: 5919931
PMID: 29700415
DOI: 10.1038/s41598-018-25016-4

[…], SMART (, CDD(, PROSITE, SUPERFAMILY (, PRINTS (, PANTHER (, COILS ( and MobiDB-lite ( accessed through InterPro version 64.0 (https […]


Analysis of 182 cerebral palsy transcriptomes points to dysregulation of trophic signalling pathways and overlap with autism

PMCID: 5911435
PMID: 29681622
DOI: 10.1038/s41398-018-0136-4

[…] stering of the majority of CP samples (Fig. ) with no apparent clustering of samples based on potential confounding factors including age, gender, sex or gestational age. GO enrichment analysis using PANTHER showed that the 263 genes downregulated in CP cases are enriched for GO categories implicated in signal transduction and cell signalling, while the 124 upregulated genes are enriched for GO ca […]


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PANTHER institution(s)
Division of Bioinformatics, Department of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA
PANTHER funding source(s)
NHGRI (NIH) [U41HG002273]; NIGMS (NIH) [U24GM088849]

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