PARADIGM-SHIFT specifications


Unique identifier OMICS_14366
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages Javascript
Computer skills Advanced
Stability Stable
Maintained Yes



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  • person_outline Joshua Stuart <>

Publication for PARADIGM-SHIFT

PARADIGM-SHIFT in publication

PMCID: 4928158
PMID: 27356755
DOI: 10.1186/s12864-016-2727-x

[…] utility of each of our predicted hotspot mutations. such functional characterization can be unequivocally improved in the future by using systematic pathway-aware algorithms such as drivernet [] and paradigm-shift [], and by integrating additional functional genomic datasets such as genomics of drug sensitivity in cancer (gdsc) []. in terms of identifying hotspot mutations in the amino acid […]

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PARADIGM-SHIFT institution(s)
Department of Biomolecular Engineering and CBSE, University of California, Santa Cruz, CA, USA; School of Medicine, University of California, San Francisco, CA, USA; Parc de Recerca Biomedica de Barcelona, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; Instituci├│ Catalana de Recerca i Estudis Avan├žats (ICREA), Barcelona, Spain; Buck Institute for Aging, Novato, CA, USA; Howard Hughes Medical Institute, University of California, Santa Cruz, CA, USA
PARADIGM-SHIFT funding source(s)
This work was supported by NSF CAREER AWARD DBI:0845783, National Cancer Institute (TCGA 5R21CA135937-02), NHGRI U54HG006097 and NCI K08 CA137153/CA.


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