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Picking images of particles in cryo-electron micrographs is an important step in solving the 3D structures of large macromolecular assemblies. However, in order to achieve sub-nanometre resolution it is often necessary to capture and process many thousands or even several millions of 2D particle images. Thus, a computational bottleneck in reaching high resolution is the accurate and automatic picking of particles from raw cryo-electron micrographs.
(Hoang., 2013) gEMpicker: a highly parallel GPU-accelerated particle picking tool for cryo-electron microscopy. BMC Struct Biol.