Uses the measurements of gene expression in a given condition as reference and calculates the signaling activity of all the signaling circuits represented in the pathways. PathAct is a web server that assess how interventions over genes can affect to signaling pathways and to the cell functionalities triggered by them. This web app implements improved robust models of signaling pathways within an advanced graphical interface that provide a unique interactive working environment in which potentially actionable genes, that could eventually become drug targets, can be easily assayed alone or in combinations.
Computational Genomics Department, Centro de Investigacion Principe Felipe (CIPF), Valencia, Spain; Bioinformatics in Rare Diseases (BiER), Centro de Investigacion Biomedica en Red de Enfermedades Raras (CIBERER), Valencia, Spain; HPC Service, University Information Services, University of Cambridge, Cambridge, UK; Functional Genomics Node, (INB, PRB2, ISCIII) at CIPF, Valencia, Spain
PathAct funding source(s)
This work was supported by Spanish Ministry of Economy and Competitiveness [BIO2014-57291-R]; ‘Plataforma de Recursos Biomoleculares y Bioinformaticos’ PT 13 /0001/0030 from the ISCIII; co-funded with European Regional Development Funds (ERDF); Generalitat Valenciana (GVA-FEDER) [PROMETEOII/2014/025]; Fundacio la MaratoTV3 ; EU FP7-People ITN Marie Curie Project [ref 316861]; EU H2020-INFRADEV-1-2015-1 ELIXIREXCELERATE [ref 676559].