An integrated dataset of human pathways and protein-protein interactions. We developed a series of rules for transforming protein interactions from pathway to binary model, and the protein interactions from seven pathway databases, including PID, BioCarta, Reactome, NetPath, INOH, SPIKE and KEGG, were transformed based on these rules. These pathway-derived binary protein interactions were integrated with PPIs from other five PPI databases including HPRD, IntAct, BioGRID, MINT and DIP.
College of Mechanical & Electronic Engineering and Automatization, National University of Defense Technology, Changsha, China; Institutes of Biomedical Sciences, Fudan University, Shanghai, China; State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China
PathPPI funding source(s)
This work was supported by the National High Technology Research and Development Program of China (2012AA020201), National Basic Research Program of China (2013CB910802, 2010CB912700), International Science & Technology Cooperation Program of China (2014DFB30020), National Natural Science Foundation of China (31000379, 31000587, 31000591), and Chinese State Key Project Specialized for Infectious Diseases (2012ZX10002012-006).