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Pathway crosstalk network prediction software tools | Pathway analysis

Cells communicate with their environment via signal transduction pathways. On occasion, the activation of one pathway can produce an effect downstream of another pathway, a phenomenon known as crosstalk.Source text:(Tegge et al., 2016) Xtalk: a…
BinoX
Desktop

BinoX

A genome wide network analysis tool. BinoX determines the statistical…

A genome wide network analysis tool. BinoX determines the statistical significance of network link enrichment or depletion between gene sets, using the binomial distribution. It may be employed for…

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PathwAX
Web

PathwAX

A webservice for pathway annotation based on crosstalk derived through FunCoup,…

A webservice for pathway annotation based on crosstalk derived through FunCoup, a framework for genome wide functional association networks. PathwAX runs the BinoX algorithm, which employs…

CrosstalkNet
Web
Desktop

CrosstalkNet

Explores interactions between tumor epithelial and stromal cells in a bipartite…

Explores interactions between tumor epithelial and stromal cells in a bipartite manner. CrosstalkNet can be used to efficiently visualize, mine, and interpret large co-expression networks. It has…

XTalk
Desktop

XTalk

A path-based approach for identifying pairs of pathways that may crosstalk.…

A path-based approach for identifying pairs of pathways that may crosstalk. XTalk computes the statistical significance of the average length of multiple short paths that connect receptors in one…

PAGI
Desktop
Web

PAGI

Identifies latent dysregulated pathways by considering the global influence of…

Identifies latent dysregulated pathways by considering the global influence of both within-pathway effects and crosstalk between pathways. Input of expression profiles with two biological states can…

CrossTalkZ
Desktop

CrossTalkZ

A statistical method and software to assess the significance of crosstalk…

A statistical method and software to assess the significance of crosstalk enrichment between pairs of gene or protein groups in large biological networks. We demonstrate that the standard z-score is…

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