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pathway Data Integration Portal pathDIP


An annotated database of signaling cascades. PathDIP integrates data from 20 source pathway databases, comprising core pathways from major curated pathways databases, and extended pathways predicted by using physical protein interactions. Data integration and predictions increase coverage of pathway annotations for protein-coding genes to 86%, and provide novel annotations for 5,732 pathway orphans. PathDIP annotates 17,070 protein-coding genes with 4,678 pathways, and provides multiple query, analysis and output options.

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pathDIP classification

pathDIP specifications

Restrictions to use:
Community driven:
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Not allowed
Database management system:
Data access:
File download, Browse

pathDIP support



  • Igor Jurisica <>


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Department of Medical Biophysics, University of Toronto, Toronto, Canada; Princess Margaret Cancer Centre, University Health Network, TMDT, Toronto, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Canada; Department of Computer Science, University of Toronto, Toronto, ON, Canada; Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia

Funding source(s)

This work was supported by the Ontario Research Fund (GL2-01-030), the Canada Research Chair Program (CRC 203373, 225404), the Ontario Research Fund (RE-03-020), the Natural Sciences Research Council (NSERC 203475), the Canada Foundation for Innovation (CFI 12301, 203373, 29272, 225404, 30865), the US Army (DOD W81XWH-1-1-0501) and IBM.

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